IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishObjective: To update the follow-up of the Euro-Lupus Nephritis Trial (ELNT), a randomised prospective trial comparing low-dose (LD) and high-dose (HD) intravenous (IV) cyclophosphamide (CY) followed by azathioprine (AZA) as treatment for proliferative lupus nephritis. Patients and methods: Data for survival and kidney function were prospectively collected during a 10-year period for the 90 patients randomised in the ELNT, except in 6 lost to follow-up. Results: Death, sustained doubling of serum creatinine and end-stage renal disease rates did not differ between the LD and HD group (5/44 (11%) vs 2/46 (4%), 6/44 (14%) vs 5/46 (11%) and 2/44 (5%) vs 4/46 (9%), respectively) nor did mean serum creatinine, 24 h proteinuria and damage score at last follow-up. Most patients in both groups were still treated with glucocorticoids, other immunosuppressant agents and blood pressure lowering drugs. After 10 years of follow-up, the positive predictive value for a good outcome of an early drop in proteinuria in response to initial immunosuppressive therapy was confirmed. Conclusion: The data confirm that a LD IVCY regimen followed by AZA - the "Euro-Lupus regimen" - achieves good clinical results in the very long term
Houssiau, F., Vasconcelos, C., D'Cruz, D., Sebastiani, G., De Ramon Garrido, E., Danieli, M., et al. (2010). The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose and high-dose intravenous cyclophosphamide. ANNALS OF THE RHEUMATIC DISEASES, 69(1), 61-64.
| Citazione: | Houssiau, F., Vasconcelos, C., D'Cruz, D., Sebastiani, G., De Ramon Garrido, E., Danieli, M., et al. (2010). The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose and high-dose intravenous cyclophosphamide. ANNALS OF THE RHEUMATIC DISEASES, 69(1), 61-64. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose and high-dose intravenous cyclophosphamide | |
| Autori: | Houssiau, F; Vasconcelos, C; D'Cruz, D; Sebastiani, G; De Ramon Garrido, E; Danieli, M; Abramovicz, D; Blockmans, D; Cauli, A; Direskeneli, H; Galeazzi, M; Gül, A; Levy, Y; Petera, P; Popovic, R; Petrovic, R; Sinico, R; Cattaneo, R; Font, J; Depresseux, G; Cosyns, J; Cervera, R | |
| Autori: | ||
| Data di pubblicazione: | 2010 | |
| Lingua: | English | |
| Rivista: | ANNALS OF THE RHEUMATIC DISEASES | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1136/ard.2008.102533 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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