Anti-C1q antibodies are found in a variety of diseases, in addition to systemic lupus erythematosus (SLE), and in 3-5% of normal individuals. In particular, anti-C1q antibodies are detected at a high titer in 100% of patients with hypocomplementemic urticarial vasculitis and in 30-48% of SLE patients. Their titer correlates with active renal disease with a sensitivity of 44-100% and a specificity of 70-92%. An increase in anti-C1q antibody titer has been suggested to be able to predict renal flares in lupus nephritis so that monitoring anti-C1q might be valuable for the clinical management of SLE patients as a noninvasive biological marker. Recently our group studied 228 patients affected by lupus nephritis and found that the association of anti-C1q, C3, and C4, in a multivariate analysis, provided the best prediction of renal flares, particularly in patients with focal and diffuse proliferative lupus nephritis and in the absence of antiphospholipid antibodies. © 2009 New York Academy of Sciences.
Sinico, R., Rimoldi, L., Radice, A., Bianchi, L., Gallelli, B., & Moroni, G. (2009). Anti-C1q autoantibodies in lupus nephritis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1173(1), 47-51 [10.1111/j.1749-6632.2009.04746.x].
Citazione: | Sinico, R., Rimoldi, L., Radice, A., Bianchi, L., Gallelli, B., & Moroni, G. (2009). Anti-C1q autoantibodies in lupus nephritis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1173(1), 47-51 [10.1111/j.1749-6632.2009.04746.x]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Anti-C1q autoantibodies in lupus nephritis | |
Autori: | Sinico, R; Rimoldi, L; Radice, A; Bianchi, L; Gallelli, B; Moroni, G | |
Autori: | ||
Data di pubblicazione: | 2009 | |
Lingua: | English | |
Rivista: | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1749-6632.2009.04746.x | |
Appare nelle tipologie: | 01 - Articolo su rivista |