The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP. © 2009 New York Academy of Sciences

Ceribelli, A., Andreoli, L., Cavazzana, I., Franceschini, F., Radice, A., Rimoldi, L., et al. (2009). Complement cascade in systemic lupus erythematosus: Analyses of the three activation pathways. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1173(1), 427-434 [10.1111/j.1749-6632.2009.04921.x].

Complement cascade in systemic lupus erythematosus: Analyses of the three activation pathways

SINICO, RENATO ALBERTO;
2009

Abstract

The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP. © 2009 New York Academy of Sciences
Articolo in rivista - Articolo scientifico
Complement (C') cascade; Complement deficiency; Complement ELISA kit; Complement pathways; Systemic lupus erythematosus (SLE); Adult; Antibodies, Antinuclear; Complement Activation; Complement C1q; Complement C2; Complement C4; Complement Pathway, Alternative; Complement Pathway, Classical; Complement Pathway, Mannose-Binding Lectin; Complement System Proteins; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Biochemistry, Genetics and Molecular Biology (all)
English
427
434
8
Ceribelli, A., Andreoli, L., Cavazzana, I., Franceschini, F., Radice, A., Rimoldi, L., et al. (2009). Complement cascade in systemic lupus erythematosus: Analyses of the three activation pathways. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1173(1), 427-434 [10.1111/j.1749-6632.2009.04921.x].
Ceribelli, A; Andreoli, L; Cavazzana, I; Franceschini, F; Radice, A; Rimoldi, L; Sinico, R; Carlsson, M; Wieslander, J; Tincani, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/139273
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