HLA-DRB4 gene is associated with Churg-Strauss syndrome (CSS), a systemic eosinophilic vasculitis with a prodromal phase characterized by severe asthma, eosinophilia, nasal polyposis, and sinusitis. Aim of this study was to evaluate if the presence of HLA-DRB4 in asthmatic patients is associated with a clinical picture resembling that of the prodromal phase of CSS. HLA-DRB1 was determined in a cohort of 159 asthmatic patients and its frequency was compared with that of 1808 blood donors. HLA-DRB4 presence/absence was correlated with clinical features, including sinusitis, nasal polyposis, eosinophils, antiasthmatic drugs, asthma severity, and pulmonary function tests. HLA-DRB4 gene was associated with severe persistent asthma before treatment (P < 0.02), near fatal or severe hypoxemic asthma (P < 0.01), sinusitis (P < 0.01), nasal polyposis (P < 0.01), number of patients with eosinophils >1000/ μ l: (P < 0.05), need of beclomethasone >1000-2000 μ g/daily (P < 0.001), use of a third controller (P < 0.05), and oral prednisone (P < 0.02). HLA-DRB4 gene is associated in asthmatic patients with a clinical picture characterized by asthma severity, sinusitis, nasal polyposis, and eosinophilia closely resembling that of the prodromal phase of CSS and might be useful to suspect corticosteroids-masked cases of CSS
Bottero, P., Motta, F., Bonini, M., Vecchio, F., Ierna, F., Cuppari, I., et al. (2014). Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?. ISRN RHEUMATOLOGY, 2014.
Citazione: | Bottero, P., Motta, F., Bonini, M., Vecchio, F., Ierna, F., Cuppari, I., et al. (2014). Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?. ISRN RHEUMATOLOGY, 2014. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome? |
Autori: | Bottero, P; Motta, F; Bonini, M; Vecchio, F; Ierna, F; Cuppari, I; Sinico, R |
Autori: | SINICO, RENATO ALBERTO (Corresponding) |
Data di pubblicazione: | 2014 |
Lingua: | English |
Rivista: | ISRN RHEUMATOLOGY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/2014/843804 |
Appare nelle tipologie: | 01 - Articolo su rivista |