Objective: Systemic vasculitis (SV) are uncommon diseases that rarely affect women during their reproductive age; little data, mainly retrospective, is available on this topic. The aim of our study was to evaluate maternal/neonatal outcome and disease course before, during and after pregnancy. Methods: Sixty-five pregnancies in 50 women with SV were followed by a multispecialistic team in 8 institutions between 1995 and 2014. Clinical data on pregnancy, 1. year before and 1. year after delivery was retrospectively collected. The rate of pregnancy complications was compared to that of a General Obstetric Population (GOP) of 3939 women. Results: In 2 patients the diagnosis of SV was done during pregnancy; 59 out of the remaining 63 started when maternal disease was quiescent. We recorded 56 deliveries with 59 live births, 8 miscarriages and 1 fetal death. In SV, preterm, particularly early preterm (<. 34. weeks) deliveries and cesarean sections appeared significantly more frequent than in GOP (11.3% vs 5.0%, p=. 0.049 and 48.2% vs 31.0%, p=. 0.009).Vasculitis-related complications occurred in 23 pregnancies (35.4%), with 5 severe events (7.7%) including 3 cases of transient ischemic attack (TIA). Data about the post-partum period were available for 56 pregnancies: 12 flares (21.4%) occurred, with 1 severe event (1.8%). Conclusion: SV patients can have successful pregnancies (especially during a disease remission phase) despite an increased rate of preterm delivery. Severe flares were limited, but the occurrence of 3 TIA suggests that particular attention should be given to possible thrombotic complications in SV patients during pregnancy and puerperium.
Fredi, M., Lazzaroni, M., Tani, C., Ramoni, V., Gerosa, M., Inverardi, F., et al. (2015). Systemic vasculitis and pregnancy: A multicenter study on maternal and neonatal outcome of 65 prospectively followed pregnancies. AUTOIMMUNITY REVIEWS, 14(8), 686-691 [10.1016/j.autrev.2015.03.009].
|Citazione:||Fredi, M., Lazzaroni, M., Tani, C., Ramoni, V., Gerosa, M., Inverardi, F., et al. (2015). Systemic vasculitis and pregnancy: A multicenter study on maternal and neonatal outcome of 65 prospectively followed pregnancies. AUTOIMMUNITY REVIEWS, 14(8), 686-691 [10.1016/j.autrev.2015.03.009].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Systemic vasculitis and pregnancy: A multicenter study on maternal and neonatal outcome of 65 prospectively followed pregnancies|
|Autori:||Fredi, M; Lazzaroni, M; Tani, C; Ramoni, V; Gerosa, M; Inverardi, F; Sfriso, P; Caramaschi, P; Andreoli, L; Sinico, R; Motta, M; Lojacono, A; Trespidi, L; Strigini, F; Brucato, A; Caporali, R; Doria, A; Guillevin, L; Meroni, P; Montecucco, C; Mosca, M; Tincani, A|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.autrev.2015.03.009|
|Appare nelle tipologie:||01 - Articolo su rivista|