Sensitized triplet–triplet annihilation based photon up-conversion (TTA-UC) greatly improves the scope and applicability of fluorescence bioimaging by enabling anti-Stokes detection at low powers, thus eliminating the background autofluorescence and limiting the potential damage of the living tissues. Here the authors present a facile, one-step protocol to prepare dual dye-doped, TTA-UC active nanomicelles starting from the commercially available surfactant Kolliphor EL, a component of several FDA approved preparations. These nanosized micelles show an unprecedented up-conversion yield of 6.5% under 0.1 W cm−2 excitation intensity in an aqueous, nondeaerated dispersion. The supramolecular architecture obtained preserves the embedded dyes from oxygen quenching, allowing satisfactory anti-Stokes fluorescence imaging of 3T3 cells. This is the first example of efficient multicomponent up-converters prepared using highly biocompatible materials approved by the international authority, paving the way for the development of new complex and multifunctional materials for advanced theranostics.

Mattiello, S., Monguzzi, A., Pedrini, J., Sassi, M., Villa, C., Torrente, Y., et al. (2016). Self-Assembled Dual Dye-Doped Nanosized Micelles for High-Contrast Up-Conversion Bioimaging. ADVANCED FUNCTIONAL MATERIALS, 26(46), 8447-8454 [10.1002/adfm.201603303].

Self-Assembled Dual Dye-Doped Nanosized Micelles for High-Contrast Up-Conversion Bioimaging

MATTIELLO, SARA
Primo
;
MONGUZZI, ANGELO MARIA
Secondo
;
PEDRINI, JACOPO;SASSI, MAURO;VILLA, CHIARA;MAROTTA, ROBERTO;MEINARDI, FRANCESCO
;
BEVERINA, LUCA
2016

Abstract

Sensitized triplet–triplet annihilation based photon up-conversion (TTA-UC) greatly improves the scope and applicability of fluorescence bioimaging by enabling anti-Stokes detection at low powers, thus eliminating the background autofluorescence and limiting the potential damage of the living tissues. Here the authors present a facile, one-step protocol to prepare dual dye-doped, TTA-UC active nanomicelles starting from the commercially available surfactant Kolliphor EL, a component of several FDA approved preparations. These nanosized micelles show an unprecedented up-conversion yield of 6.5% under 0.1 W cm−2 excitation intensity in an aqueous, nondeaerated dispersion. The supramolecular architecture obtained preserves the embedded dyes from oxygen quenching, allowing satisfactory anti-Stokes fluorescence imaging of 3T3 cells. This is the first example of efficient multicomponent up-converters prepared using highly biocompatible materials approved by the international authority, paving the way for the development of new complex and multifunctional materials for advanced theranostics.
Articolo in rivista - Articolo scientifico
anti-Stokes imaging; high biocompatibility; multicomponent nanomaterials; photon up-conversion; self-assembled superstructures;
English
8447
8454
8
Mattiello, S., Monguzzi, A., Pedrini, J., Sassi, M., Villa, C., Torrente, Y., et al. (2016). Self-Assembled Dual Dye-Doped Nanosized Micelles for High-Contrast Up-Conversion Bioimaging. ADVANCED FUNCTIONAL MATERIALS, 26(46), 8447-8454 [10.1002/adfm.201603303].
Mattiello, S; Monguzzi, A; Pedrini, J; Sassi, M; Villa, C; Torrente, Y; Marotta, R; Meinardi, F; Beverina, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/139047
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