DNA double-strand breaks (DSBs) are a nasty form of damage that needs to be repaired to ensure genome stability. The DSB ends can undergo a strand-biased nucleolytic processing (resection) to generate 3′-ended single-stranded DNA (ssDNA) that channels DSB repair into homologous recombination. Generation of ssDNA also triggers the activation of the DNA damage checkpoint, which couples cell cycle progression with DSB repair. The checkpoint response is intimately linked to DSB resection, as some checkpoint proteins regulate the resection process. The present review will highlight recent works on the mechanism and regulation of DSB resection and its interplays with checkpoint activation/inactivation in budding yeast.
VILLA, M., CASSANI, C., GOBBINI, E., BONETTI, D., & LONGHESE, M. (2016). Coupling end resection with the checkpoint response at DNA double-strand breaks. CELLULAR AND MOLECULAR LIFE SCIENCES, 73(19), 3655-3663 [10.1007/s00018-016-2262-6].
Citazione: | VILLA, M., CASSANI, C., GOBBINI, E., BONETTI, D., & LONGHESE, M. (2016). Coupling end resection with the checkpoint response at DNA double-strand breaks. CELLULAR AND MOLECULAR LIFE SCIENCES, 73(19), 3655-3663 [10.1007/s00018-016-2262-6]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Coupling end resection with the checkpoint response at DNA double-strand breaks | |
Autori: | VILLA, M; CASSANI, C; GOBBINI, E; BONETTI, D; LONGHESE, M | |
Autori: | VILLA, MATTEO (Primo) CASSANI, CORINNE (Secondo) GOBBINI, ELISA (Penultimo) LONGHESE, MARIA PIA (Ultimo) (Corresponding) | |
Data di pubblicazione: | 2016 | |
Lingua: | English | |
Rivista: | CELLULAR AND MOLECULAR LIFE SCIENCES | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00018-016-2262-6 | |
Appare nelle tipologie: | 01 - Articolo su rivista |