DNA double-strand breaks (DSBs) are a nasty form of damage that needs to be repaired to ensure genome stability. The DSB ends can undergo a strand-biased nucleolytic processing (resection) to generate 3′-ended single-stranded DNA (ssDNA) that channels DSB repair into homologous recombination. Generation of ssDNA also triggers the activation of the DNA damage checkpoint, which couples cell cycle progression with DSB repair. The checkpoint response is intimately linked to DSB resection, as some checkpoint proteins regulate the resection process. The present review will highlight recent works on the mechanism and regulation of DSB resection and its interplays with checkpoint activation/inactivation in budding yeast.

Villa, M., Cassani, C., Gobbini, E., Bonetti, D., Longhese, M. (2016). Coupling end resection with the checkpoint response at DNA double-strand breaks. CELLULAR AND MOLECULAR LIFE SCIENCES, 73(19), 3655-3663 [10.1007/s00018-016-2262-6].

Coupling end resection with the checkpoint response at DNA double-strand breaks

VILLA, MATTEO
Primo
;
CASSANI, CORINNE
Secondo
;
GOBBINI, ELISA
Penultimo
;
BONETTI, DIEGO;LONGHESE, MARIA PIA
Ultimo
2016

Abstract

DNA double-strand breaks (DSBs) are a nasty form of damage that needs to be repaired to ensure genome stability. The DSB ends can undergo a strand-biased nucleolytic processing (resection) to generate 3′-ended single-stranded DNA (ssDNA) that channels DSB repair into homologous recombination. Generation of ssDNA also triggers the activation of the DNA damage checkpoint, which couples cell cycle progression with DSB repair. The checkpoint response is intimately linked to DSB resection, as some checkpoint proteins regulate the resection process. The present review will highlight recent works on the mechanism and regulation of DSB resection and its interplays with checkpoint activation/inactivation in budding yeast.
Articolo in rivista - Articolo scientifico
Double-strand break; Mec1; MRX; Nucleases; Resection; Tel1;
Double-strand break; MRX; Mec1; Nucleases; Resection; Tel1
English
3655
3663
9
Villa, M., Cassani, C., Gobbini, E., Bonetti, D., Longhese, M. (2016). Coupling end resection with the checkpoint response at DNA double-strand breaks. CELLULAR AND MOLECULAR LIFE SCIENCES, 73(19), 3655-3663 [10.1007/s00018-016-2262-6].
Villa, M; Cassani, C; Gobbini, E; Bonetti, D; Longhese, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/138714
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