Caveolin-1 and flotillin-1 belong to plasma membrane microdomains. They are characterized by peculiar lipid and protein composition and are involved in fundamental cellular events such as: signal transduction, cell adhesion, lipid/protein sorting, and human cancer. We addressed caveolin-1 and flotillin-1 expression in 30 human renal cell carcinoma (RCC) and adjacent normal kidney (ANK) samples by SDS-PAGE and immunoblotting with specific antibodies. Significant caveolin-1 and flotillin-1 over-expression was found in RCC tissues compared to ANK, and was confirmed by immunohistochemistry. Caveolin-1 and flotillin-1 protein levels were found by 1-D, 2-DE, and MS to be increased also in RCC microdomain-enriched subcellular fractions purified from paired RCC and ANK samples.
Raimondo, F., Ticozzi Valerio, D., Magni, F., Perego, R., Bianchi, C., Sarto, C., et al. (2008). Caveolin-1 and Flotillin-1 Differential Expression in Clinical Samples of Renal Cell Carcinoma. THE OPEN PROTEOMICS JOURNAL, 1, 87-98.
Citazione: | Raimondo, F., Ticozzi Valerio, D., Magni, F., Perego, R., Bianchi, C., Sarto, C., et al. (2008). Caveolin-1 and Flotillin-1 Differential Expression in Clinical Samples of Renal Cell Carcinoma. THE OPEN PROTEOMICS JOURNAL, 1, 87-98. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Caveolin-1 and Flotillin-1 Differential Expression in Clinical Samples of Renal Cell Carcinoma | |
Autori: | Raimondo, F; Ticozzi Valerio, D; Magni, F; Perego, R; Bianchi, C; Sarto, C; Casellato, S; Fasoli, E; Ferrero, S; Cifola, I; Rocco, F; Kienle, MD; Mocarelli, P; Brambilla, P; Pitto, M | |
Autori: | ||
Data di pubblicazione: | 2008 | |
Lingua: | English | |
Rivista: | THE OPEN PROTEOMICS JOURNAL | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/1875039700801010079 | |
Appare nelle tipologie: | 01 - Articolo su rivista |