The gastrointestinal tract is colonized with a highly different population of bacterial, viral, ad fungal species; viruses are reported to be dominant. The composition of gut virome is closely related to dietary habits and surrounding environment. Host and their intestinal microbes live in a dynamic equilibrium and viruses stimulate a low degree of immune responses without causing symptoms (host tolerance). However, intestinal phages could lead to a rupture of eubiosis and may contribute to the shift from health to disease in humans and animals. Viral nucleic acids and other products of lysis of bacteria serve as pathogen-associated molecular patterns (PAMPs) and could trigger specific inflammatory modulations. At the same time, phages could elicit innate antiviral immune responses. Toll-like receptors (TLRs) operated as innate antiviral immune sensors and their activation triggers signaling cascades that lead to inflammatory response. J. Med. Virol. 88:1467–1472, 2016. © 2016 Wiley Periodicals, Inc.
Columpsi P., Sacchi P., Zuccaro V., Cima S., Sarda C., Mariani M., et al. (2016). Beyond the gut bacterial microbiota: The gut virome. JOURNAL OF MEDICAL VIROLOGY, 88(9), 1467-1472 [10.1002/jmv.24508].
Citazione: | Columpsi P., Sacchi P., Zuccaro V., Cima S., Sarda C., Mariani M., et al. (2016). Beyond the gut bacterial microbiota: The gut virome. JOURNAL OF MEDICAL VIROLOGY, 88(9), 1467-1472 [10.1002/jmv.24508]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
Titolo: | Beyond the gut bacterial microbiota: The gut virome | |
Autori: | Columpsi P.; Sacchi P.; Zuccaro V.; Cima S.; Sarda C.; Mariani M.; Gori A.; Bruno R. | |
Autori: | ||
Data di pubblicazione: | 2016 | |
Lingua: | English | |
Rivista: | JOURNAL OF MEDICAL VIROLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/jmv.24508 | |
Appare nelle tipologie: | 01 - Articolo su rivista |