The gastrointestinal tract is colonized with a highly different population of bacterial, viral, ad fungal species; viruses are reported to be dominant. The composition of gut virome is closely related to dietary habits and surrounding environment. Host and their intestinal microbes live in a dynamic equilibrium and viruses stimulate a low degree of immune responses without causing symptoms (host tolerance). However, intestinal phages could lead to a rupture of eubiosis and may contribute to the shift from health to disease in humans and animals. Viral nucleic acids and other products of lysis of bacteria serve as pathogen-associated molecular patterns (PAMPs) and could trigger specific inflammatory modulations. At the same time, phages could elicit innate antiviral immune responses. Toll-like receptors (TLRs) operated as innate antiviral immune sensors and their activation triggers signaling cascades that lead to inflammatory response. J. Med. Virol. 88:1467–1472, 2016. © 2016 Wiley Periodicals, Inc.

Columpsi, P., Sacchi, P., Zuccaro, V., Cima, S., Sarda, C., Mariani, M., et al. (2016). Beyond the gut bacterial microbiota: The gut virome. JOURNAL OF MEDICAL VIROLOGY, 88(9), 1467-1472 [10.1002/jmv.24508].

Beyond the gut bacterial microbiota: The gut virome

Gori, A;
2016

Abstract

The gastrointestinal tract is colonized with a highly different population of bacterial, viral, ad fungal species; viruses are reported to be dominant. The composition of gut virome is closely related to dietary habits and surrounding environment. Host and their intestinal microbes live in a dynamic equilibrium and viruses stimulate a low degree of immune responses without causing symptoms (host tolerance). However, intestinal phages could lead to a rupture of eubiosis and may contribute to the shift from health to disease in humans and animals. Viral nucleic acids and other products of lysis of bacteria serve as pathogen-associated molecular patterns (PAMPs) and could trigger specific inflammatory modulations. At the same time, phages could elicit innate antiviral immune responses. Toll-like receptors (TLRs) operated as innate antiviral immune sensors and their activation triggers signaling cascades that lead to inflammatory response. J. Med. Virol. 88:1467–1472, 2016. © 2016 Wiley Periodicals, Inc.
Articolo in rivista - Articolo scientifico
gut virome; microbiota; ultra deep sequencing;
Gut virome; Microbiota; Ultra deep sequencing; Virology; Infectious Diseases
English
1467
1472
6
Columpsi, P., Sacchi, P., Zuccaro, V., Cima, S., Sarda, C., Mariani, M., et al. (2016). Beyond the gut bacterial microbiota: The gut virome. JOURNAL OF MEDICAL VIROLOGY, 88(9), 1467-1472 [10.1002/jmv.24508].
Columpsi, P; Sacchi, P; Zuccaro, V; Cima, S; Sarda, C; Mariani, M; Gori, A; Bruno, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/138109
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