The surgical treatment of liver metastasis due to colorectal cancer can substantially modify the natural history of the disease, mainly when it is associated with effective medical treatment. Chemotherapy, via systemic or locoregional (intrahepatic) administration, has 2 possible objectives: as adjuvant treatment, to prevent or delay disease recurrence; as neo-adjuvant treatment, mainly interesting for the surgeon, to allow resective surgery in responding patients previously considered not-operable. Unfortunately, the severe immune deficiency associated with the advanced cancer negative impact on long-term outcome after any treatment (surgery, chemotherapy) is a limit for the clinical application of multidisciplinary treatments. Aim of this study is to review the possible different approaches to improve the clinical results, either as tumour response or overall survival, using an association of IL-2 with different chemotherapy procedures, in order to recover the locoregional and/or systemic immunodeficency. Several literature studies are worth of consideration not only for the biological activity reported, but also for the preliminary clinical results. At our Department, we have started a clinical experience in order to verify and confirm the results reported in these studies. The preliminary results seem to confirm an increase of chemotherapy activity obtained with an association of IL-2 immunotherapy with systemic therapy procedures and mainly with locoregional therapeutic programs

Brivio, F., Fumagalli, L., Fattori, L., Nespoli, L., Denova, M., Sargenti, E., et al. (2004). Clinical role of interleukin-2 in the surgical treatment of liver metastasis due to colon adenocarcinoma. MINERVA CHIRURGICA, 59(6), 573-582.

Clinical role of interleukin-2 in the surgical treatment of liver metastasis due to colon adenocarcinoma

NESPOLI, LUCA CARLO;NESPOLI, ANGELO
2004

Abstract

The surgical treatment of liver metastasis due to colorectal cancer can substantially modify the natural history of the disease, mainly when it is associated with effective medical treatment. Chemotherapy, via systemic or locoregional (intrahepatic) administration, has 2 possible objectives: as adjuvant treatment, to prevent or delay disease recurrence; as neo-adjuvant treatment, mainly interesting for the surgeon, to allow resective surgery in responding patients previously considered not-operable. Unfortunately, the severe immune deficiency associated with the advanced cancer negative impact on long-term outcome after any treatment (surgery, chemotherapy) is a limit for the clinical application of multidisciplinary treatments. Aim of this study is to review the possible different approaches to improve the clinical results, either as tumour response or overall survival, using an association of IL-2 with different chemotherapy procedures, in order to recover the locoregional and/or systemic immunodeficency. Several literature studies are worth of consideration not only for the biological activity reported, but also for the preliminary clinical results. At our Department, we have started a clinical experience in order to verify and confirm the results reported in these studies. The preliminary results seem to confirm an increase of chemotherapy activity obtained with an association of IL-2 immunotherapy with systemic therapy procedures and mainly with locoregional therapeutic programs
Articolo in rivista - Articolo scientifico
Antimetabolites, Antineoplastic; Randomized Controlled Trials as Topic; Time Factors; Fluorouracil; Colonic Neoplasms; Hepatic Artery; Adenocarcinoma; Humans; Liver Neoplasms; Immunotherapy; Antineoplastic Agents; Follow-Up Studies; Infusions, Intra-Arterial; Interleukin-2; Injections, Subcutaneous; Preoperative Care; Postoperative Care; Combined Modality Therapy
Italian
2004
59
6
573
582
none
Brivio, F., Fumagalli, L., Fattori, L., Nespoli, L., Denova, M., Sargenti, E., et al. (2004). Clinical role of interleukin-2 in the surgical treatment of liver metastasis due to colon adenocarcinoma. MINERVA CHIRURGICA, 59(6), 573-582.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/13783
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