IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishBackground: Little is known about the involvement of human herpesviruses 6 and 7 (HHV-6 and HHV-7) in autoimmune connective tissue diseases (ACTD). Objective: To determine the prevalence of active infection with HHV-6 and HHV-7 in patients with ACTD. Study design: The presence and quantity of HHV-6 DNA was determined by quantitative real-time PCR in a cross-sectional study of serum, peripheral blood mononuclear cells, and tissues obtained from 58 ACTD patients and 38 healthy subjects (HS). Specific anti-HHV-6 antibody titer was also measured. Results: HHV-6 serum viremia occurred in a significantly higher proportion of ACTD patients compared to HS [26/58 (44.8%) vs. 1/38 (2.6%), p = 0.001] with the highest reactivation frequency [7/10 (70%)] observed in patients with scleroderma. Moreover, HHV-6 in serum was associated with ACTD activity (22/38 vs. 4/20, p < 0.05). Higher titers of HHV-6 antibodies were found in ACTD patients than in HS, although HHV-6 seroprevalence among patients with ACTD and HS was similar. HHV-7 viremia was not detected in any patients or HS controls. Conclusion: The frequent reactivation of HHV-6 in scleroderma and other ACTD, especially when active, suggests that HHV-6 may play a role in the pathogenesis of these diseases. © 2009 Elsevier B.V. All rights reserved
Broccolo, F., Drago, F., Paolino, S., Cassina, G., Gatto, F., Fusetti, L., et al. (2009). Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. JOURNAL OF CLINICAL VIROLOGY, 46(1), 43-46.
| Citazione: | Broccolo, F., Drago, F., Paolino, S., Cassina, G., Gatto, F., Fusetti, L., et al. (2009). Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. JOURNAL OF CLINICAL VIROLOGY, 46(1), 43-46. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases | |
| Autori: | Broccolo, F; Drago, F; Paolino, S; Cassina, G; Gatto, F; Fusetti, L; Matteoli, B; Zaccaria, E; Parodi, A; Lusso, P; Ceccherini-Nelli, L; Malnati, M | |
| Autori: | ||
| Data di pubblicazione: | 2009 | |
| Lingua: | English | |
| Rivista: | JOURNAL OF CLINICAL VIROLOGY | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jcv.2009.05.010 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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