Background: Little is known about the involvement of human herpesviruses 6 and 7 (HHV-6 and HHV-7) in autoimmune connective tissue diseases (ACTD). Objective: To determine the prevalence of active infection with HHV-6 and HHV-7 in patients with ACTD. Study design: The presence and quantity of HHV-6 DNA was determined by quantitative real-time PCR in a cross-sectional study of serum, peripheral blood mononuclear cells, and tissues obtained from 58 ACTD patients and 38 healthy subjects (HS). Specific anti-HHV-6 antibody titer was also measured. Results: HHV-6 serum viremia occurred in a significantly higher proportion of ACTD patients compared to HS [26/58 (44.8%) vs. 1/38 (2.6%), p = 0.001] with the highest reactivation frequency [7/10 (70%)] observed in patients with scleroderma. Moreover, HHV-6 in serum was associated with ACTD activity (22/38 vs. 4/20, p < 0.05). Higher titers of HHV-6 antibodies were found in ACTD patients than in HS, although HHV-6 seroprevalence among patients with ACTD and HS was similar. HHV-7 viremia was not detected in any patients or HS controls. Conclusion: The frequent reactivation of HHV-6 in scleroderma and other ACTD, especially when active, suggests that HHV-6 may play a role in the pathogenesis of these diseases. © 2009 Elsevier B.V. All rights reserved

Broccolo, F., Drago, F., Paolino, S., Cassina, G., Gatto, F., Fusetti, L., et al. (2009). Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. JOURNAL OF CLINICAL VIROLOGY, 46(1), 43-46 [10.1016/j.jcv.2009.05.010].

Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases

BROCCOLO, FRANCESCO
;
GATTO, FRANCESCA;FUSETTI, LISA;
2009

Abstract

Background: Little is known about the involvement of human herpesviruses 6 and 7 (HHV-6 and HHV-7) in autoimmune connective tissue diseases (ACTD). Objective: To determine the prevalence of active infection with HHV-6 and HHV-7 in patients with ACTD. Study design: The presence and quantity of HHV-6 DNA was determined by quantitative real-time PCR in a cross-sectional study of serum, peripheral blood mononuclear cells, and tissues obtained from 58 ACTD patients and 38 healthy subjects (HS). Specific anti-HHV-6 antibody titer was also measured. Results: HHV-6 serum viremia occurred in a significantly higher proportion of ACTD patients compared to HS [26/58 (44.8%) vs. 1/38 (2.6%), p = 0.001] with the highest reactivation frequency [7/10 (70%)] observed in patients with scleroderma. Moreover, HHV-6 in serum was associated with ACTD activity (22/38 vs. 4/20, p < 0.05). Higher titers of HHV-6 antibodies were found in ACTD patients than in HS, although HHV-6 seroprevalence among patients with ACTD and HS was similar. HHV-7 viremia was not detected in any patients or HS controls. Conclusion: The frequent reactivation of HHV-6 in scleroderma and other ACTD, especially when active, suggests that HHV-6 may play a role in the pathogenesis of these diseases. © 2009 Elsevier B.V. All rights reserved
Articolo in rivista - Articolo scientifico
Connective tissue diseases; Herpesviruses; HHV-6; Real-time PCR; Viral load; Viral reactivation; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; Autoimmune Diseases; Child; Connective Tissue Diseases; Cross-Sectional Studies; DNA, Viral; Female; Herpesvirus 6, Human; Herpesvirus 7, Human; Humans; Male; Middle Aged; Polymerase Chain Reaction; Prevalence; Roseolovirus Infections; Viremia; Young Adult; Virus Activation; Medicine (all); Virology; Infectious Diseases
English
43
46
4
Broccolo, F., Drago, F., Paolino, S., Cassina, G., Gatto, F., Fusetti, L., et al. (2009). Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. JOURNAL OF CLINICAL VIROLOGY, 46(1), 43-46 [10.1016/j.jcv.2009.05.010].
Broccolo, F; Drago, F; Paolino, S; Cassina, G; Gatto, F; Fusetti, L; Matteoli, B; Zaccaria, E; Parodi, A; Lusso, P; Ceccherini Nelli, L; Malnati, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/136578
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