IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishBackground: In clinical trials, toxicity leading to tenofovir disoproxil fumarate (TDF) discontinuation is rare (3% by 2 years); however in clinical practice it seems to be higher, particularlywhen TDF is co-administered with ritonavir-boosted protease inhibitors (PI/r). Aims of this study were to assess the rate of TDF discontinuations in clinical practice and to identify factors associated with the risk of stopping TDF. Methods: All antiretroviral treatment (ART)-naive patients initiating a TDF-based regimen were selected from the ICONA Foundation Study cohort. The primary outcome was TDF discontinuation regardless of the reason; secondary outcome measures were TDF discontinuation due to toxicity and selective TDF discontinuation (that is, TDF discontinuation or substitution, maintaining unchanged the remaining antiretroviral treatment). Results: 3,618 ART-naïve patients were included: 54% started a PI/r-based and 46% a NNRTIbased based regimen. Two-hundred-seventy-seven patients discontinued TDF and reintroduced ART within 30 days without TDF. The probability of TDF discontinuation regardless of the reason was of 7.4% (95%CI:6.4-8.5) by 2 years and 14.1% (95%CI:12.2-16.1) by 5 years. The 5-year KM estimates in the PI/r vs. NNRTI group were 20.4% vs. 7.6%, respectively (log-rank p = 0.0001), for the outcome of stopping regardless of the reason, and 10.7% vs. 4.7% (p = 0.0001) for discontinuation due to toxicity. PI/r use and lower eGFR were associated with an increased risk of discontinuing TDF. Conclusion: In our cohort, the frequency of TDF discontinuations was higher than that observed in clinical trials. Co-administration of TDF with PI/r was associated with an increased rate of TDF discontinuations. Further studies are needed to clarify the mechanisms that might have led to this outcome.
Costarelli, S., Cozzi-Lepri, A., Lapadula, G., Bonora, S., Madeddu, G., Maggiolo, F., et al. (2016). Long-term durability of tenofovir-based antiretroviral therapy In relation to the Co-administration of other drug classes in routine clinical practice. PLOS ONE, 11(10).
| Citazione: | Costarelli, S., Cozzi-Lepri, A., Lapadula, G., Bonora, S., Madeddu, G., Maggiolo, F., et al. (2016). Long-term durability of tenofovir-based antiretroviral therapy In relation to the Co-administration of other drug classes in routine clinical practice. PLOS ONE, 11(10). |
| Tipo: | Articolo in rivista - Articolo scientifico |
| Carattere della pubblicazione: | Scientifica |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si |
| Titolo: | Long-term durability of tenofovir-based antiretroviral therapy In relation to the Co-administration of other drug classes in routine clinical practice |
| Autori: | Costarelli, S; Cozzi-Lepri, A; Lapadula, G; Bonora, S; Madeddu, G; Maggiolo, F; Antinori, A; Galli, M; Di Perri, G; Viale, P; D'Arminio Monforte, A; Gori, A; Moroni, M; Andreoni, M; Angarano, G; Castelli, F; Cauda, R; Iardino, R; Ippolito, G; Lazzarin, A; Perno, C; Von Schloesser, F; Castagna, A; Ceccherini-Silberstein, F; Girardi, E; Lo Caputo, S; Mussini, C; Puoti, M; Ammassari, A; Balotta, C; Bonfanti, P; Borderi, M; Capobianchi, M; Cingolani, A; Cinque, P; De Luca, A; Di Biagio, A; Gianotti, N; Guaraldi, G; Lichtner, M; Marchetti, G; Marcotullio, S; Monno, L; Quiros Roldan, E; Rusconi, S; Saracino, A; Cicconi, P; Fanti, I; Galli, L; Lorenzini, P; Tavelli, A; Giacometti, A; Costantini, A; Mazzoccato, S; Santoro, C; Suardi, C; Vanino, E; Verucchi, G; Minardi, C; Quirino, T; Abeli, C; Manconi, P; Piano, P; Vecchiet, J; Falasca, K; Sighinolfi, L; Segala, D; Mazzotta, F; Cassola, G; Viscoli, C; Alessandrini, A; Piscopo, R; Mazzarello, G; Mastroianni, C; Belvisi, V; Caramma, I; Chiodera, A; Castelli, A; Rizzardini, G; Ridolfo, A; Piolini, R; Salpietro, S; Carenzi, L; Moioli, M; Tincati, C; Puzzolante, C; Abrescia, N; Chirianni, A; Guida, M; Gargiulo, M; Baldelli, F; Francisci, D; Parruti, G; Ursini, T; Magnani, G; Ursitti, M; Vullo, V; D'Avino, A; Gallo, L; Nicastri, E; Acinapura, R; Capozzi, M; Libertone, R; Tebano, G; Cattelan, A; Sasset, L; Mura, M; Rossetti, B; Caramello, P; Orofino, G; Sciandra, M; Bassetti, M; Londero, A; Pellizzer, G; Manfrin, V |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Lingua: | English |
| Rivista: | PLOS ONE |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1371/journal.pone.0160761 |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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| Long-Term Durability of Tenofovir-Based.pdf | N/A | Open Access Visualizza/Apri |
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