Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes

Granucci, F., Zanoni, I., Feau, S., Ricciardi Castagnoli, P. (2003). Dendritic cell regulation of immune responses: A new role for interleukin 2 at the intersection of innate and adaptive immunity. EMBO JOURNAL, 22(11), 2546-2551 [10.1093/emboj/cdg261].

Dendritic cell regulation of immune responses: A new role for interleukin 2 at the intersection of innate and adaptive immunity

GRANUCCI, FRANCESCA;ZANONI, IVAN;
2003

Abstract

Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes
Recensione in rivista
Models, Immunological; Dendritic Cells; Cell Communication; Interleukin-2; Cell Differentiation; Animals; B-Lymphocytes; T-Lymphocytes; Killer Cells, Natural; Immunity, Innate; Humans
English
2003
22
11
2546
2551
reserved
Granucci, F., Zanoni, I., Feau, S., Ricciardi Castagnoli, P. (2003). Dendritic cell regulation of immune responses: A new role for interleukin 2 at the intersection of innate and adaptive immunity. EMBO JOURNAL, 22(11), 2546-2551 [10.1093/emboj/cdg261].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/134597
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