Background: MRSA is a therapeutic concern worldwide, and a major agent of community-acquired skin and soft tissue infections (CA-SSTIs). While the US epidemiology of MRSA in CA-SSTIs is well described and reports the high prevalence of the USA300 clone, data on the European situation are lacking. Objectives: To determine the prevalence and clonal characteristics of MRSA in CA-SSTIs in seven European emergency departments. Patients and methods: From April to June 2015, patients presenting to the tertiary hospital emergency department with a Staphylococcus aureus CA-SSTI were prospectively enrolled. S. aureus isolates were characterized by antimicrobial susceptibility testing, detection of Panton-Valentine leucocidin encoding genes and spa-typing, MLST and/or DNA microarray. Results: Two-hundred and five cases of S. aureus-associated CA-SSTIs were included, comprising folliculitis, furuncles, abscesses, paronychia, impetigo, carbuncles and cellulitis. Of the 205 cases, we report an MRSA prevalence rate of 15.1%, with a north (0%) to south (29%) increasing gradient. Fifty-one isolates were Panton-Valentine leucocidin-positive (24.9%), whether MSSA or MRSA, with a heterogeneous distribution between countries. Clonal distribution of MSSA and MRSA showed high diversity, with no predominant circulating clone and no archetypical USA300 CA-MRSA clone. Conclusions: This original prospective multicentre study highlights stark differences in European MRSA epidemiology compared with the USA, and that the USA300 CA-MRSA clone is not predominant among communityinfected patients in Europe.
Bouchiat, C., Curtis, S., Spiliopoulou, I., Bes, M., Cocuzza, C., Codita, I., et al. (2017). MRSA infections among patients in the emergency department: A European multicentre study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72(2), 372-375 [10.1093/jac/dkw431].
|Citazione:||Bouchiat, C., Curtis, S., Spiliopoulou, I., Bes, M., Cocuzza, C., Codita, I., et al. (2017). MRSA infections among patients in the emergency department: A European multicentre study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72(2), 372-375 [10.1093/jac/dkw431].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||MRSA infections among patients in the emergency department: A European multicentre study|
|Autori:||Bouchiat, C; Curtis, S; Spiliopoulou, I; Bes, M; Cocuzza, C; Codita, I; Dupieux, C; Giormezis, N; Kearns, A; Laurent, F; Molinos, S; Musumeci, R; Prat, C; Saadatian Elahi, M; Tacconelli, E; Tristan, A; Schulte, B; Vandenesch, F|
|Data di pubblicazione:||2017|
|Rivista:||JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/jac/dkw431|
|Appare nelle tipologie:||01 - Articolo su rivista|