In vertebrates, microorganisms are recognized by pathogen recognition receptors (PRRs). Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of genes. Within these genes, the cytokines family plays a crucial function because of its role in adaptive immunity induction and in tissue-specific functional regulation, such as tissue repair and tissue homeostasis during steady state conditions. Within the myeloid compartment, dendritic cells (DCs) release a variety of inflammatory cytokines in response to microbes. In this study, we show that BMDCs release IL-22 directly upon PRRs activation without the need of IL-23 signaling as reported for other IL22-producing cells. Moreover, we demonstrate that cytokine IL-22 is rapidly released in a cell-specific manner as macrophages are not able to produce IL-22 through the same PRRs system. In addition, we characterize the intracellular signaling cascade required for IL-22 release in BMDCs. Myd88, MEK1/2, NFkb and AhR, but not p38, NFAT, and RORgt, were found to be involved in IL-22 regulation in DCs. Our study suggests that BMDCs possess a unique intracellular molecular plasticity which, once activated, directs different BMDCs functions in a cell-specific manner.
Fumagalli, S., Torri, A., Papagna, A., Citterio, S., Mainoldi, F., & Foti, M. (2016). IL-22 is rapidly induced by Pathogen Recognition Receptors Stimulation in Bone-Marrow-derived Dendritic Cells in the Absence of IL-23. SCIENTIFIC REPORTS, 6 [10.1038/srep33900].
Citazione: | Fumagalli, S., Torri, A., Papagna, A., Citterio, S., Mainoldi, F., & Foti, M. (2016). IL-22 is rapidly induced by Pathogen Recognition Receptors Stimulation in Bone-Marrow-derived Dendritic Cells in the Absence of IL-23. SCIENTIFIC REPORTS, 6 [10.1038/srep33900]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | IL-22 is rapidly induced by Pathogen Recognition Receptors Stimulation in Bone-Marrow-derived Dendritic Cells in the Absence of IL-23 | |
Autori: | Fumagalli, S; Torri, A; Papagna, A; Citterio, S; Mainoldi, F; Foti, M | |
Autori: | FUMAGALLI, SILVIA (Primo) TORRI, ANNA (Secondo) FOTI, MARIA (Corresponding) | |
Data di pubblicazione: | 2016 | |
Lingua: | English | |
Rivista: | SCIENTIFIC REPORTS | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/srep33900 | |
Appare nelle tipologie: | 01 - Articolo su rivista |
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