We are proposing a regularized reconstruction strategy for the detection of bone lesions in 18F-fluoride whole body PET images obtained with 1 min/ bed using the anatomical information provided by co-registered CT images. Bones are recognized on CT images and then transposed into the PET volume framework. During PET reconstruction, two different priors are used for bone and non-bone voxels: the relative difference prior in bone and the P-Gaussian prior in non-bone. After a tuning of the priors' parameters, the reconstruction strategy has been tested on 6 18F-fluoride PET/CT studies, on a total of 67 lesions. Regularized images provided results comparable to the standard 3 min/bed images, in terms image quality, lesion activity, noise level and noise correlation. The proposed strategy therefore appears to be a useful tool to reduce the acquisition time or the injected dose in 18F-fluoride PET studies.

DE BERNARDI, E., Magnani, P., Gianolli, L., Gilardi, M., Bettinardi, V. (2015). Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies. PHYSICS IN MEDICINE AND BIOLOGY, 60(1), 67-80 [10.1088/0031-9155/60/1/67].

Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies

DE BERNARDI, ELISABETTA
Primo
;
GILARDI, MARIA CARLA
Penultimo
;
2015

Abstract

We are proposing a regularized reconstruction strategy for the detection of bone lesions in 18F-fluoride whole body PET images obtained with 1 min/ bed using the anatomical information provided by co-registered CT images. Bones are recognized on CT images and then transposed into the PET volume framework. During PET reconstruction, two different priors are used for bone and non-bone voxels: the relative difference prior in bone and the P-Gaussian prior in non-bone. After a tuning of the priors' parameters, the reconstruction strategy has been tested on 6 18F-fluoride PET/CT studies, on a total of 67 lesions. Regularized images provided results comparable to the standard 3 min/bed images, in terms image quality, lesion activity, noise level and noise correlation. The proposed strategy therefore appears to be a useful tool to reduce the acquisition time or the injected dose in 18F-fluoride PET studies.
Articolo in rivista - Articolo scientifico
18F-fluoride PET; Bone segmentation; Dose/acquisition time reduction; Regularized maximum likelihood reconstruction; Algorithms; Artifacts; Bone Neoplasms; Bone and Bones; Humans; Image Processing, Computer-Assisted; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Fluorodeoxyglucose F18; Radiology, Nuclear Medicine and Imaging; Radiological and Ultrasound Technology; Medicine (all)
English
67
80
14
DE BERNARDI, E., Magnani, P., Gianolli, L., Gilardi, M., Bettinardi, V. (2015). Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies. PHYSICS IN MEDICINE AND BIOLOGY, 60(1), 67-80 [10.1088/0031-9155/60/1/67].
DE BERNARDI, E; Magnani, P; Gianolli, L; Gilardi, M; Bettinardi, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/132915
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