We are proposing a regularized reconstruction strategy for the detection of bone lesions in 18F-fluoride whole body PET images obtained with 1 min/ bed using the anatomical information provided by co-registered CT images. Bones are recognized on CT images and then transposed into the PET volume framework. During PET reconstruction, two different priors are used for bone and non-bone voxels: the relative difference prior in bone and the P-Gaussian prior in non-bone. After a tuning of the priors' parameters, the reconstruction strategy has been tested on 6 18F-fluoride PET/CT studies, on a total of 67 lesions. Regularized images provided results comparable to the standard 3 min/bed images, in terms image quality, lesion activity, noise level and noise correlation. The proposed strategy therefore appears to be a useful tool to reduce the acquisition time or the injected dose in 18F-fluoride PET studies.
DE BERNARDI, E., Magnani, P., Gianolli, L., GILARDI, M., & Bettinardi, V. (2015). Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies. PHYSICS IN MEDICINE AND BIOLOGY, 60(1), 67-80.
Citazione: | DE BERNARDI, E., Magnani, P., Gianolli, L., GILARDI, M., & Bettinardi, V. (2015). Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies. PHYSICS IN MEDICINE AND BIOLOGY, 60(1), 67-80. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies |
Autori: | DE BERNARDI, E; Magnani, P; Gianolli, L; GILARDI, M; Bettinardi, V |
Autori: | GILARDI, MARIA CARLA (Penultimo) |
Data di pubblicazione: | 2015 |
Lingua: | English |
Rivista: | PHYSICS IN MEDICINE AND BIOLOGY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1088/0031-9155/60/1/67 |
Appare nelle tipologie: | 01 - Articolo su rivista |