Dendritic cells (DCs) have an important role in the activation of NK cells that exert direct antitumor and antimicrobial effects and can influence the development of adaptive T cell responses. DCs acquire NK cell stimulatory capacity after exposure to various stimuli. In this study we investigated the nature of the stimuli that confer to DCs the NK cell-activating capacity. After exposure of DCs to TLR-dependent and -independent microbial stimuli and to nonmicrobial stimuli, we evaluated the ability of activated DCs to elicit IFN-gamma production from NK cells in vitro and to promote NK cell activation in vivo. We show in this study that only TLR-dependent microbial stimuli typically associated with Th1 responses confer to DCs the ability to activate NK cells, whereas stimuli associated with Th2 responses do not have this property.
Citazione: | Zanoni, I., Foti, M., Ricciardi-Castagnoli, P., & Granucci, F. (2005). TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells. JOURNAL OF IMMUNOLOGY, 175(1), 286-292. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells |
Autori: | Zanoni, I; Foti, M; Ricciardi-Castagnoli, P; Granucci, F |
Autori: | |
Data di pubblicazione: | 2005 |
Lingua: | English |
Rivista: | JOURNAL OF IMMUNOLOGY |
Appare nelle tipologie: | 01 - Articolo su rivista |
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