Endocrine profiles and neuropsychologic correlates of functional hypothalamic amenorrhea in adolescents

Objective: To determine trigger factors and neuropsychologic correlates of functional hypothalamic amenorrhea (FHA) in adolescence and to evaluate the correlations with the endocrine-metabolic profile. Design: Cross-sectional comparison of adolescents with FHA and eumenorrheic controls Setting: Academic medical institution Patient(s): Twenty adolescent girls with FHA (aged _18 years) and 20 normal cycling girls Intervention(s): All subjects underwent endocrine-gynecologic (hormone) and neuropsychiatric (tests and interview) investigations. A separate semistructured interview was also used to investigate parents. Main Outcome Measure(s): Gonadotropins, leptin, prolactin, androgens, estrogens, cortisol, carrier proteins (SHBG, insulin-like growth factor– binding protein 1), and metabolic parameters (insulin, insulin-like growth factor 1, thyroid hormones) were assayed in FHA and control subjects. All girls were evaluated using a test for depression, a test for disordered eating, and a psychodynamic semistructured interview. Result(s): Adolescents with FHA showed a particular susceptibility to common life events, restrictive disordered eating, depressive traits, and psychosomatic disorders. The endocrine-metabolic profile was strictly correlated to the severity of the psychopathology. Conclusion(s): Functional hypothalamic amenorrhea in adolescence is due to a particular neuropsychologic vulnerability to stress, probably related to familial relationship styles, expressed by a proportional endocrine impairment. (Fertil Steril_ 2007;87:876–85. ©2007 by American Society for Reproductive Medicine.) Key Words: Functional hypothalamic amenorrhea, hormone profile, adolescence, trigger factors, life events, eating disorders, psychosomatic disorders, depressive traits