Objective: To determine trigger factors and neuropsychologic correlates of functional hypothalamic amenorrhea (FHA) in adolescence and to evaluate the correlations with the endocrine-metabolic profile. Design: Cross-sectional comparison of adolescents with FHA and eumenorrheic controls Setting: Academic medical institution Patient(s): Twenty adolescent girls with FHA (aged _18 years) and 20 normal cycling girls Intervention(s): All subjects underwent endocrine-gynecologic (hormone) and neuropsychiatric (tests and interview) investigations. A separate semistructured interview was also used to investigate parents. Main Outcome Measure(s): Gonadotropins, leptin, prolactin, androgens, estrogens, cortisol, carrier proteins (SHBG, insulin-like growth factor– binding protein 1), and metabolic parameters (insulin, insulin-like growth factor 1, thyroid hormones) were assayed in FHA and control subjects. All girls were evaluated using a test for depression, a test for disordered eating, and a psychodynamic semistructured interview. Result(s): Adolescents with FHA showed a particular susceptibility to common life events, restrictive disordered eating, depressive traits, and psychosomatic disorders. The endocrine-metabolic profile was strictly correlated to the severity of the psychopathology. Conclusion(s): Functional hypothalamic amenorrhea in adolescence is due to a particular neuropsychologic vulnerability to stress, probably related to familial relationship styles, expressed by a proportional endocrine impairment. (Fertil Steril_ 2007;87:876–85. ©2007 by American Society for Reproductive Medicine.) Key Words: Functional hypothalamic amenorrhea, hormone profile, adolescence, trigger factors, life events, eating disorders, psychosomatic disorders, depressive traits

Bomba, M., Gambera, A., Bonini, L., Peroni, M., Neri, F., Scagliola, P., et al. (2007). Endocrine profiles and neuropsychologic correlates of functional hypothalamic amenorrhea in adolescents. FERTILITY AND STERILITY, 87(4), 876-885 [10.1016/j.fertnstert.2006.09.011].

Endocrine profiles and neuropsychologic correlates of functional hypothalamic amenorrhea in adolescents

NERI, FRANCESCA;NACINOVICH, RENATA
2007

Abstract

Objective: To determine trigger factors and neuropsychologic correlates of functional hypothalamic amenorrhea (FHA) in adolescence and to evaluate the correlations with the endocrine-metabolic profile. Design: Cross-sectional comparison of adolescents with FHA and eumenorrheic controls Setting: Academic medical institution Patient(s): Twenty adolescent girls with FHA (aged _18 years) and 20 normal cycling girls Intervention(s): All subjects underwent endocrine-gynecologic (hormone) and neuropsychiatric (tests and interview) investigations. A separate semistructured interview was also used to investigate parents. Main Outcome Measure(s): Gonadotropins, leptin, prolactin, androgens, estrogens, cortisol, carrier proteins (SHBG, insulin-like growth factor– binding protein 1), and metabolic parameters (insulin, insulin-like growth factor 1, thyroid hormones) were assayed in FHA and control subjects. All girls were evaluated using a test for depression, a test for disordered eating, and a psychodynamic semistructured interview. Result(s): Adolescents with FHA showed a particular susceptibility to common life events, restrictive disordered eating, depressive traits, and psychosomatic disorders. The endocrine-metabolic profile was strictly correlated to the severity of the psychopathology. Conclusion(s): Functional hypothalamic amenorrhea in adolescence is due to a particular neuropsychologic vulnerability to stress, probably related to familial relationship styles, expressed by a proportional endocrine impairment. (Fertil Steril_ 2007;87:876–85. ©2007 by American Society for Reproductive Medicine.) Key Words: Functional hypothalamic amenorrhea, hormone profile, adolescence, trigger factors, life events, eating disorders, psychosomatic disorders, depressive traits
Articolo in rivista - Articolo scientifico
endocrine,amenorrhea
English
2007
87
4
876
885
none
Bomba, M., Gambera, A., Bonini, L., Peroni, M., Neri, F., Scagliola, P., et al. (2007). Endocrine profiles and neuropsychologic correlates of functional hypothalamic amenorrhea in adolescents. FERTILITY AND STERILITY, 87(4), 876-885 [10.1016/j.fertnstert.2006.09.011].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/13188
Citazioni
  • Scopus 58
  • ???jsp.display-item.citation.isi??? 44
Social impact