The Carey–Finema–Ziter syndrome (CFZS, MIM 254940) is an apparently autosomal recessively inherited disorder consisting of the combination of non-progressive congenital myopathy with Moebius and Pierre Robin sequence, facial anomalies and growth delay. Mental development has been described as normal or delayed. Temporomandibular joint (TMJ) ankylosis is the immobility of the joint caused by ankylotic fusion of the mandible to the cranial base or zygoma. It is a serious and disabling condition that may cause problems in mastication, digestion, speech, appearance, and oral hygiene. Most often is a true ankylosis of the TMJ but other pathological mechanisms are described (i.e., the fusion of the coronoid process to temporal bone or with the zygoma, or a variety of soft tissues disorders like Fibrodysplasia Ossificans Progressiva). Here we report a 2-year-old girl fitting with a clinical diagnosis of CFZS associated with a limited mouth opening in which temporomandibular joint ankylosis was suspected. Because it has been postulated that many clinical features in CFZS may only be secondary effects of brainstem anomalies and muscle weakness during development, the limited opening of the mouth observed in our patient could represent a rare clinical feature of CFZS itself. © 2016 Wiley Periodicals, Inc.

Pasetti, M., Mazzoleni, F., Novelli, G., Iascone, M., Bozzetti, A., Selicorni, A. (2016). Temporomandibular joint ankylosis as part of the clinical spectrum of Carey–Fineman–Ziter syndrome?. AMERICAN JOURNAL OF MEDICAL GENETICS. PART A, 170(8), 2191-2195 [10.1002/ajmg.a.37767].

Temporomandibular joint ankylosis as part of the clinical spectrum of Carey–Fineman–Ziter syndrome?

PASETTI, MARTINA
Primo
;
MAZZOLENI, FABIO
Secondo
;
Novelli, G;BOZZETTI, ALBERTO
Penultimo
;
2016

Abstract

The Carey–Finema–Ziter syndrome (CFZS, MIM 254940) is an apparently autosomal recessively inherited disorder consisting of the combination of non-progressive congenital myopathy with Moebius and Pierre Robin sequence, facial anomalies and growth delay. Mental development has been described as normal or delayed. Temporomandibular joint (TMJ) ankylosis is the immobility of the joint caused by ankylotic fusion of the mandible to the cranial base or zygoma. It is a serious and disabling condition that may cause problems in mastication, digestion, speech, appearance, and oral hygiene. Most often is a true ankylosis of the TMJ but other pathological mechanisms are described (i.e., the fusion of the coronoid process to temporal bone or with the zygoma, or a variety of soft tissues disorders like Fibrodysplasia Ossificans Progressiva). Here we report a 2-year-old girl fitting with a clinical diagnosis of CFZS associated with a limited mouth opening in which temporomandibular joint ankylosis was suspected. Because it has been postulated that many clinical features in CFZS may only be secondary effects of brainstem anomalies and muscle weakness during development, the limited opening of the mouth observed in our patient could represent a rare clinical feature of CFZS itself. © 2016 Wiley Periodicals, Inc.
Articolo in rivista - Articolo scientifico
Carey–Fineman–Ziter syndrome; temporomandibular joint ankylosis;
Carey–Fineman–Ziter syndrome; temporomandibular joint ankylosis; Genetics (clinical); Genetics
English
2016
170
8
2191
2195
reserved
Pasetti, M., Mazzoleni, F., Novelli, G., Iascone, M., Bozzetti, A., Selicorni, A. (2016). Temporomandibular joint ankylosis as part of the clinical spectrum of Carey–Fineman–Ziter syndrome?. AMERICAN JOURNAL OF MEDICAL GENETICS. PART A, 170(8), 2191-2195 [10.1002/ajmg.a.37767].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/131156
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