Purpose To assess if radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) may influence the evaluation of perfusion parameters obtained with CT-perfusion (CT-p) in HCC treated patients. Materials and methods Thirty-three consecutive cirrhotic patients with biopsy-proven diagnosis of HCC lesions and candidates to TACE or RFA were included. The CT-p study of hepatic parenchyma and of treated lesions was performed about 1 month after treatment on 16 multidetector CT after injection of 50 mL of non ionic contrast agent (350 mg I/mL) at a flow rate of 6 mL/s acquiring 40 dynamic scans. A dedicated perfusion software which generated a quantitative map of arterial and portal perfusion by means of colour scale was employed.The following perfusion parameters were assessed before and after RFA or TACE treatment: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), time to peak (TTP), hepatic perfusion index (HPI). Results A complete treatment was obtained in 16 cases and incomplete treatment in the 17 remaining cases. The perfusion data of completely treated lesions were: HP 10.2 ± 6.3; AP 10.4 ± 7; BV 4.05 ± 4.8; TTP 38.9 ± 4.2; HPI 9.9 ± 9.2, whereas in partially treated lesions were: HP 43.2 ± 15.1 mL/s/100 g; AP 38.7 ± 8.8 mL/min; BV 20.7 ± 9.5 mL/100 mg; TTP 24 ± 3.7 s; HPI 61.7 ± 7.5%. In adjacent cirrhotic parenchyma, the parameters of all evaluated patients were: HP 13.2 ± 4; AP 12.3 ± 3.4; BV 11.8 ± 2.8; TTP 43.9 ± 2.9; and HPI 17.1 ± 9.8. A significant difference (P < 0.001) was found for all parameters between residual viable tumor tissue (P < 0.001) compared to successfully treated lesion due to the presence of residual arterial vascular structure in viable portion of treated HCC. Conclusion According to our results, CT-p evaluation is not influenced by TACE or RFA treatments, thus representing a feasible technique that allows a reproducible quantitative evaluation of treatment response in HCC patients. © 2014 Elsevier Ireland Ltd.
Ippolito, D., Fior, D., Bonaffini, P., Capraro, C., Leni, D., Corso, R., et al. (2014). Quantitative evaluation of CT-perfusion map as indicator of tumor response to transarterial chemoembolization and radiofrequency ablation in HCC patients. EUROPEAN JOURNAL OF RADIOLOGY, 83(9), 1665-1671 [10.1016/j.ejrad.2014.05.040].
|Citazione:||Ippolito, D., Fior, D., Bonaffini, P., Capraro, C., Leni, D., Corso, R., et al. (2014). Quantitative evaluation of CT-perfusion map as indicator of tumor response to transarterial chemoembolization and radiofrequency ablation in HCC patients. EUROPEAN JOURNAL OF RADIOLOGY, 83(9), 1665-1671 [10.1016/j.ejrad.2014.05.040].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Quantitative evaluation of CT-perfusion map as indicator of tumor response to transarterial chemoembolization and radiofrequency ablation in HCC patients|
|Autori:||Ippolito, D; Fior, D; Bonaffini, P; Capraro, C; Leni, D; Corso, R; Sironi, S|
IPPOLITO, DAVIDE (Primo)
FIOR, DAVIDE (Secondo)
SIRONI, SANDRO (Ultimo)
|Data di pubblicazione:||2014|
|Rivista:||EUROPEAN JOURNAL OF RADIOLOGY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejrad.2014.05.040|
|Appare nelle tipologie:||01 - Articolo su rivista|