Background: Aim of the study was to determine the value of perfusion computed tomography in the quantitative assessment of tumour-related neoangiogenesis for the diagnosis and treatment of hepatocellular carcinoma lesions. Methods: Overall, 47 consecutive patients with cirrhotic liver disease, with a high risk of hepatocellular carcinoma, and undergoing standard surveillance (six-month intervals) were eligible for inclusion in this prospective study; based on Barcelona Clinic Liver Cancer guidelines, 27 patients were enrolled. Perfusion computed tomography was performed in 29 biopsy-proven hepatocellular carcinoma lesions before and after treatment with transarterial chemoembolization or radiofrequency ablation. The dynamic study was performed with a 256-slice multidetector-computed tomography scanner; the following parameters were measured: hepatic perfusion, arterial perfusion, blood volume, hepatic perfusion index, and time-to-peak in all patients. Results: Hepatocellular carcinoma lesions had the following median perfusion values: perfusion 46.3. mL/min/100. g; blood volume 20.4. mL/100. mg; arterial perfusion 42.9. mL/min; hepatic perfusion index 92.5%; time to peak 18.7. s. Significantly lower perfusion values were obtained in correctly treated lesions or surrounding parenchyma than in viable hepatocellular carcinoma tissue. Conclusions: In hepatocellular carcinoma, perfusion computed tomography could contribute to a non-invasive quantification of tumour blood supply related to the formation of new arterial structures, and enable the assessment of therapeutic response

Ippolito, D., Fior, D., TALEI FRANZESI, C., Capraro, C., Casiraghi, A., Leni, D., et al. (2014). Tumour-related neoangiogenesis: Functional dynamic perfusion computed tomography for diagnosis and treatment efficacy assessment in hepatocellular carcinoma. DIGESTIVE AND LIVER DISEASE, 46(10), 916-922 [10.1016/j.dld.2014.06.002].

Tumour-related neoangiogenesis: Functional dynamic perfusion computed tomography for diagnosis and treatment efficacy assessment in hepatocellular carcinoma

IPPOLITO, DAVIDE
Primo
;
FIOR, DAVIDE
Secondo
;
TALEI FRANZESI, CAMMILLO ROBERTO GIOVANNI LEOPOLDO;CAPRARO, CRISTINA;CASIRAGHI, ALESSANDRA SILVIA;VACIRCA, FRANCESCO;SIRONI, SANDRO
Ultimo
2014

Abstract

Background: Aim of the study was to determine the value of perfusion computed tomography in the quantitative assessment of tumour-related neoangiogenesis for the diagnosis and treatment of hepatocellular carcinoma lesions. Methods: Overall, 47 consecutive patients with cirrhotic liver disease, with a high risk of hepatocellular carcinoma, and undergoing standard surveillance (six-month intervals) were eligible for inclusion in this prospective study; based on Barcelona Clinic Liver Cancer guidelines, 27 patients were enrolled. Perfusion computed tomography was performed in 29 biopsy-proven hepatocellular carcinoma lesions before and after treatment with transarterial chemoembolization or radiofrequency ablation. The dynamic study was performed with a 256-slice multidetector-computed tomography scanner; the following parameters were measured: hepatic perfusion, arterial perfusion, blood volume, hepatic perfusion index, and time-to-peak in all patients. Results: Hepatocellular carcinoma lesions had the following median perfusion values: perfusion 46.3. mL/min/100. g; blood volume 20.4. mL/100. mg; arterial perfusion 42.9. mL/min; hepatic perfusion index 92.5%; time to peak 18.7. s. Significantly lower perfusion values were obtained in correctly treated lesions or surrounding parenchyma than in viable hepatocellular carcinoma tissue. Conclusions: In hepatocellular carcinoma, perfusion computed tomography could contribute to a non-invasive quantification of tumour blood supply related to the formation of new arterial structures, and enable the assessment of therapeutic response
Articolo in rivista - Articolo scientifico
CT-perfusion; Hepatocellular carcinoma; MDCT; Neoangiogenesis; Radiofrequency ablation; Trans-arterial chemoembolization; Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Middle Aged; Multidetector Computed Tomography; Neovascularization, Pathologic; Prospective Studies; Treatment Outcome; Catheter Ablation; Chemoembolization, Therapeutic; Gastroenterology; Hepatology; Medicine (all)
English
916
922
7
Ippolito, D., Fior, D., TALEI FRANZESI, C., Capraro, C., Casiraghi, A., Leni, D., et al. (2014). Tumour-related neoangiogenesis: Functional dynamic perfusion computed tomography for diagnosis and treatment efficacy assessment in hepatocellular carcinoma. DIGESTIVE AND LIVER DISEASE, 46(10), 916-922 [10.1016/j.dld.2014.06.002].
Ippolito, D; Fior, D; TALEI FRANZESI, C; Capraro, C; Casiraghi, A; Leni, D; Vacirca, F; Corso, R; Sironi, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/130988
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