Objectives To evaluate intrareader and inter-reader agreement in CT perfusion (Perf) measurements in cirrhotic patients with hepatocellular carcinoma (HCC) lesions. Methods Sixteen patients with HCC (9 untreated, 5 recurrence/residual disease after transarterial chemoembolization, and 2 after radiofrequency ablation treatment) underwent standard CT examination and a Perf study; a quantitative map of arterial and portal Perf by means of a color scale was generated. With dedicated Perf software, the following parameters were calculated on untreated and treated HCC lesions and on cirrhotic parenchyma: hepatic Perf, tissue blood volume, hepatic perfusion index, arterial perfusion, and time to peak. Intraobserver and interobserver agreements were assessed for 2 readers with Bland-Altman plots, intraclass correlation coefficients (ICCs), coefficients of variation, and repeatability. Results In HCC lesions, agreement analysis demonstrated higher intra-agreement values in comparison with interagreement (range of ICC values, 0.26-0.59 between readers and 0.67-0.94 between readings). Lower interagreement was found for treated HCC lesions in comparison with untreated lesions (range of ICC values, respectively, 0.12-0.54 and 0.31-0.89). Conclusions For all Perf parameters intra-agreement was higher than interagreement, even though a relatively wide range of 95% limits of agreement was found in both cases.

Ippolito, D., Casiraghi, A., TALEI FRANZESI, C., Bonaffini, P., Fior, D., Sironi, S. (2016). Intraobserver and interobserver agreement in the evaluation of tumor vascularization with computed tomography perfusion in cirrhotic patients with hepatocellular carcinoma. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 40(1), 152-159 [10.1097/RCT.0000000000000331].

Intraobserver and interobserver agreement in the evaluation of tumor vascularization with computed tomography perfusion in cirrhotic patients with hepatocellular carcinoma

IPPOLITO, DAVIDE
Primo
;
CASIRAGHI, ALESSANDRA SILVIA
Secondo
;
TALEI FRANZESI, CAMMILLO ROBERTO GIOVANNI LEOPOLDO;BONAFFINI, PIETRO ANDREA;FIOR, DAVIDE
Penultimo
;
SIRONI, SANDRO
Ultimo
2016

Abstract

Objectives To evaluate intrareader and inter-reader agreement in CT perfusion (Perf) measurements in cirrhotic patients with hepatocellular carcinoma (HCC) lesions. Methods Sixteen patients with HCC (9 untreated, 5 recurrence/residual disease after transarterial chemoembolization, and 2 after radiofrequency ablation treatment) underwent standard CT examination and a Perf study; a quantitative map of arterial and portal Perf by means of a color scale was generated. With dedicated Perf software, the following parameters were calculated on untreated and treated HCC lesions and on cirrhotic parenchyma: hepatic Perf, tissue blood volume, hepatic perfusion index, arterial perfusion, and time to peak. Intraobserver and interobserver agreements were assessed for 2 readers with Bland-Altman plots, intraclass correlation coefficients (ICCs), coefficients of variation, and repeatability. Results In HCC lesions, agreement analysis demonstrated higher intra-agreement values in comparison with interagreement (range of ICC values, 0.26-0.59 between readers and 0.67-0.94 between readings). Lower interagreement was found for treated HCC lesions in comparison with untreated lesions (range of ICC values, respectively, 0.12-0.54 and 0.31-0.89). Conclusions For all Perf parameters intra-agreement was higher than interagreement, even though a relatively wide range of 95% limits of agreement was found in both cases.
Articolo in rivista - Articolo scientifico
computed tomography; CT perfusion; hepatocellular carcinoma; observer agreement;
computed tomography; CT perfusion; hepatocellular carcinoma; observer agreement; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Observer Variation; Reproducibility of Results; Sensitivity and Specificity; Multidetector Computed Tomography; Radiology, Nuclear Medicine and Imaging; Medicine (all)
English
152
159
8
Ippolito, D., Casiraghi, A., TALEI FRANZESI, C., Bonaffini, P., Fior, D., Sironi, S. (2016). Intraobserver and interobserver agreement in the evaluation of tumor vascularization with computed tomography perfusion in cirrhotic patients with hepatocellular carcinoma. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 40(1), 152-159 [10.1097/RCT.0000000000000331].
Ippolito, D; Casiraghi, A; TALEI FRANZESI, C; Bonaffini, P; Fior, D; Sironi, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/130980
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