Mitotic exit and cytokinesis must be tightly coupled to nuclear division both in time and space in order to preserve genome stability and to ensure that daughter cells inherit the right set of chromosomes after cell division. This is achieved in budding yeast through control over a signal transduction cascade, the mitotic exit network (MEN), which is required for mitotic CDK inactivation in telophase and for cytokinesis. Current models of MEN activation emphasize on the bud as the place where most control is exerted. This review focuses on recent data that instead point to the mother cell as being the residence of key regulators of late mitotic events.

Piatti, S., Venturetti, M., Chiroli, E., & Fraschini, R. (2006). The spindle position checkpoint in budding yeast: the motherly care of MEN. CELL DIVISION, 1(2), 1-6 [10.1186/1747-1028-1-2].

The spindle position checkpoint in budding yeast: the motherly care of MEN.

PIATTI, SIMONETTA;FRASCHINI, ROBERTA
2006-04-03

Abstract

Mitotic exit and cytokinesis must be tightly coupled to nuclear division both in time and space in order to preserve genome stability and to ensure that daughter cells inherit the right set of chromosomes after cell division. This is achieved in budding yeast through control over a signal transduction cascade, the mitotic exit network (MEN), which is required for mitotic CDK inactivation in telophase and for cytokinesis. Current models of MEN activation emphasize on the bud as the place where most control is exerted. This review focuses on recent data that instead point to the mother cell as being the residence of key regulators of late mitotic events.
Articolo in rivista - Articolo scientifico
Scientifica
checkpoint, mitosis
English
1
6
Piatti, S., Venturetti, M., Chiroli, E., & Fraschini, R. (2006). The spindle position checkpoint in budding yeast: the motherly care of MEN. CELL DIVISION, 1(2), 1-6 [10.1186/1747-1028-1-2].
Piatti, S; Venturetti, M; Chiroli, E; Fraschini, R
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/12649
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