Objectives: To measure persistence with antihypertensive drug therapy in patients initiating treatment with mono or combination therapy. Methods: Data analysis was based on two cohorts of patients, that is, a cohort derived from the registration of drug prescriptions in all residents of the Lombardy region receiving Public Health Service and a cohort of patients followed by general practitioners throughout the Italian territory. Data were limited to patients aged 40-80 years who received their first antihypertensive drug prescription (n = 433680 and 41199, respectively) in whom persistency of treatment was examined over 9 months. A proportional hazards model was fitted to estimate the association between the pattern of initial antihypertensive drug therapy and risk of treatment discontinuation. Data were adjusted for available potential confounders. Results: Taking patients starting with diuretic monotherapy as reference, the adjusted risk of treatment discontinuation was progressively lower in patients starting with monotherapy other than a diuretic, a two-drug combination, including a diuretic and a two-drug combination without a diuretic. No significant difference in the risk of discontinuation was seen between extemporaneous and fixed dose combinations, including a diuretic, that is, the only combination reimbursable by Public Health Service and, thus, available in the database. Data were similar for the two cohorts. Conclusion: Initiating treatment with a combination of two drugs is associated with a reduced risk of treatment discontinuation. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Corrao, G., Parodi, A., Zambon, A., Heiman, F., Filippi, A., Cricelli, C., et al. (2010). Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. JOURNAL OF HYPERTENSION, 28(7), 1584-1590.
|Citazione:||Corrao, G., Parodi, A., Zambon, A., Heiman, F., Filippi, A., Cricelli, C., et al. (2010). Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. JOURNAL OF HYPERTENSION, 28(7), 1584-1590.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice|
|Autori:||Corrao, G; Parodi, A; Zambon, A; Heiman, F; Filippi, A; Cricelli, C; Merlino, L; Mancia, G|
|Data di pubblicazione:||lug-2010|
|Rivista:||JOURNAL OF HYPERTENSION|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/HJH.0b013e328339f9fa|
|Appare nelle tipologie:||01 - Articolo su rivista|