Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving both upper and lower motor neurons, leading inexorably to death within a few years. Although our understanding of the pathogenesis of this disease has grown at a very fast rate in recent years, we do not yet have effective treatment options that can positively impact the quality of life (QoL) of these patients. Interestingly, increasing experimental evidence suggests that oxidative stress is involved in the pathogenesis of ALS and that vitamin E could reduce neuronal damage. Hence, in this observational study we determined the QoL in 33 ALS patients taking or not taking vitamin E supplementation (600 mg/day), using the Italian version of the Short-Form 36-Item Health Survey (SF-36). No differences were seen between the two groups of patients, therefore we do not recommend routine use of vitamin E in ALS patients, at least in the absence of randomised clinical trials specifically designed for addressing this issue

Galbussera, A., Tremolizzo, L., Brighina, L., Testa, D., Lovati, R., Ferrarese, C., et al. (2006). Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study. NEUROLOGICAL SCIENCES, 27(3), 190-193 [10.1007/s10072-006-0668-x].

Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study

GALBUSSERA, ALESSIO;TREMOLIZZO, LUCIO;BRIGHINA, LAURA;FERRARESE, CARLO;CAVALETTI, GUIDO ANGELO;
2006

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving both upper and lower motor neurons, leading inexorably to death within a few years. Although our understanding of the pathogenesis of this disease has grown at a very fast rate in recent years, we do not yet have effective treatment options that can positively impact the quality of life (QoL) of these patients. Interestingly, increasing experimental evidence suggests that oxidative stress is involved in the pathogenesis of ALS and that vitamin E could reduce neuronal damage. Hence, in this observational study we determined the QoL in 33 ALS patients taking or not taking vitamin E supplementation (600 mg/day), using the Italian version of the Short-Form 36-Item Health Survey (SF-36). No differences were seen between the two groups of patients, therefore we do not recommend routine use of vitamin E in ALS patients, at least in the absence of randomised clinical trials specifically designed for addressing this issue
Articolo in rivista - Articolo scientifico
ALS
English
2006
27
3
190
193
none
Galbussera, A., Tremolizzo, L., Brighina, L., Testa, D., Lovati, R., Ferrarese, C., et al. (2006). Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study. NEUROLOGICAL SCIENCES, 27(3), 190-193 [10.1007/s10072-006-0668-x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/11925
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