Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd.

Carra', G., Crocamo, C., Bartoli, F., Lax, A., Tremolada, M., Lucii, C., et al. (2016). First-generation antipsychotics and QTc: any role for mediating variables?. HUMAN PSYCHOPHARMACOLOGY, 31(4), 313-318 [10.1002/hup.2540].

First-generation antipsychotics and QTc: any role for mediating variables?

CARRA', GIUSEPPE
Primo
;
CROCAMO, CRISTINA
;
BARTOLI, FRANCESCO;LAX, ANNAMARIA;TREMOLADA, MARTINA;CLERICI, MASSIMO
Penultimo
;
2016

Abstract

Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd.
Articolo in rivista - Articolo scientifico
alcohol; antipsychotic agents; drug therapy combination; QT prolongation; risk factors;
antipsychotic agents; QT prolongation; alcohol; drug therapy combination; risk factors
English
313
318
6
Carra', G., Crocamo, C., Bartoli, F., Lax, A., Tremolada, M., Lucii, C., et al. (2016). First-generation antipsychotics and QTc: any role for mediating variables?. HUMAN PSYCHOPHARMACOLOGY, 31(4), 313-318 [10.1002/hup.2540].
Carra', G; Crocamo, C; Bartoli, F; Lax, A; Tremolada, M; Lucii, C; Martinotti, G; Nosè, M; Bighelli, I; Ostuzzi, G; Castellazzi, M; Clerici, M; Barbui, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/114649
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