Sleep deprivation produces deficits in hippocampal synaptic plasticity and hippocampal-dependent memory storage. Recent evidence suggests that sleep deprivation disrupts memory consolidation through multiple mechanisms, including the down-regulation of the cAMP-response element-binding protein (CREB) and of mammalian target of rapamycin (mTOR) signaling. In this study, we tested the effects of a Bioactive Dietary Polyphenol Preparation (BDPP), comprised of grape seed polyphenol extract, Concord grape juice, and resveratrol, on the attenuation of sleep deprivation-induced cognitive impairment. We found that BDPP significantly improves sleep deprivation-induced contextual memory deficits, possibly through the activation of CREB and mTOR signaling pathways. We also identified brain-available polyphenol metabolites from BDPP, among which quercetin-3-O-glucuronide activates CREB signaling and malvidin-3-O-glucoside activates mTOR signaling. In combination, quercetin and malvidin-glucoside significantly attenuated sleep deprivation-induced cognitive impairment in -a mouse model of acute sleep deprivation. Our data suggests the feasibility of using select brain-targeting polyphenol compounds derived from BDPP as potential therapeutic agents in promoting resilience against sleep deprivation-induced cognitive dysfunction.
Zhao, W., Wang, J., Bi, W., Ferruzzi, M., Yemul, S., Freire, D., et al. (2015). Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction. NEUROCHEMISTRY INTERNATIONAL, 89, 191-197.
Citazione: | Zhao, W., Wang, J., Bi, W., Ferruzzi, M., Yemul, S., Freire, D., et al. (2015). Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction. NEUROCHEMISTRY INTERNATIONAL, 89, 191-197. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | Si |
Titolo: | Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction |
Autori: | Zhao, W; Wang, J; Bi, W; Ferruzzi, M; Yemul, S; Freire, D; Mazzola, P; Ho, L; Dubner, L; Pasinetti, G |
Autori: | |
Data di pubblicazione: | 2015 |
Lingua: | English |
Rivista: | NEUROCHEMISTRY INTERNATIONAL |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.neuint.2015.07.023 |
Appare nelle tipologie: | 01 - Articolo su rivista |
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