Specific HLA alleles and immunoregulatory genes have been evaluated in primary biliary cirrhosis (PBC), but data are discordant. We determined whether TNF-α promoter polymorphisms (G-308A and G-238A) and alleles of HLA class II (HLA-DRB1) might be associated either with PBC occurrence and severity in Italian populations from two distinct areas. The distribution of TNF1 (G/G) genotype did not differ either between patients and controls or between patients from Northern and Southern Italy. Contrariwise, the HLA-DRB1*08 appeared positively linked to the occurrence of disease (8.4% in patients vs. 2.5% in controls, P = 0.003), whereas the HLA-DRB1*13 appeared to be protective, being more frequent in controls (12.8%) than in patients (7%) (P = 0.038). Neither positively nor negatively associated alleles of the two genomic loci had an effect on disease progression. We report a distinct genetic risk of developing PBC in the Italian population, with no interaction between the HLA and TNF alleles. © 2009 New York Academy of Sciences

Niro, G., Poli, F., Andriulli, A., Bianchi, I., Bernuzzi, F., Caliari, L., et al. (2009). TNF-α polymorphisms in primary biliary cirrhosis: A Northern and Southern Italian experience. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1173, 557-563 [10.1111/j.1749-6632.2009.04741.x].

TNF-α polymorphisms in primary biliary cirrhosis: A Northern and Southern Italian experience

Bernuzzi, Francesca Veronica;INVERNIZZI, PIETRO
2009

Abstract

Specific HLA alleles and immunoregulatory genes have been evaluated in primary biliary cirrhosis (PBC), but data are discordant. We determined whether TNF-α promoter polymorphisms (G-308A and G-238A) and alleles of HLA class II (HLA-DRB1) might be associated either with PBC occurrence and severity in Italian populations from two distinct areas. The distribution of TNF1 (G/G) genotype did not differ either between patients and controls or between patients from Northern and Southern Italy. Contrariwise, the HLA-DRB1*08 appeared positively linked to the occurrence of disease (8.4% in patients vs. 2.5% in controls, P = 0.003), whereas the HLA-DRB1*13 appeared to be protective, being more frequent in controls (12.8%) than in patients (7%) (P = 0.038). Neither positively nor negatively associated alleles of the two genomic loci had an effect on disease progression. We report a distinct genetic risk of developing PBC in the Italian population, with no interaction between the HLA and TNF alleles. © 2009 New York Academy of Sciences
Articolo in rivista - Articolo scientifico
Alleles; HLA-DRB1; Liver disease progression; Primary biliary cirrhosis; TNF- α alleles and genotypes; Adult; Aged; Alleles; Disease Progression; Female; Gene Frequency; Genotype; Geography; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Italy; Liver Cirrhosis, Biliary; Male; Middle Aged; Polymerase Chain Reaction; Promoter Regions, Genetic; Tumor Necrosis Factor-alpha; Polymorphism, Genetic; Biochemistry, Genetics and Molecular Biology (all)
English
557
563
7
Niro, G., Poli, F., Andriulli, A., Bianchi, I., Bernuzzi, F., Caliari, L., et al. (2009). TNF-α polymorphisms in primary biliary cirrhosis: A Northern and Southern Italian experience. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1173, 557-563 [10.1111/j.1749-6632.2009.04741.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/106399
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