Neocorticogenesis in mice homozygous for an Emx2 null allele is the topic of this article. The development of both main components of neocortex, primordial plexiform layer derivatives and cortical plate, was analyzed, paying special attention to radial migration of neurons forming the cortical plate. The products of the Reelin gene, normally playing a key role in orchestrating radial migration of these neurons, display normal distribution at the beginning of the cortical neuronogenesis but are absent in the neocortical marginal zone of the mutant mice at the time when the cortical plate is laid down. As a consequence, the development of radial glia is impaired, and neurons making up the cortical plate display abnormal migration patterns. In addition, restricted defects along the rostrocaudal and the mediolateral axes are present in the subplate, suggesting an Emx2-specific role in priming the proper development of this layer.

Mallamaci, A., Mercurio, S., Muzio, L., Cecchi, C., Pardini, C., Gruss, P., et al. (2000). The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex. THE JOURNAL OF NEUROSCIENCE, 20(3), 1109-1118.

The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex

MERCURIO, SARA
Secondo
;
2000

Abstract

Neocorticogenesis in mice homozygous for an Emx2 null allele is the topic of this article. The development of both main components of neocortex, primordial plexiform layer derivatives and cortical plate, was analyzed, paying special attention to radial migration of neurons forming the cortical plate. The products of the Reelin gene, normally playing a key role in orchestrating radial migration of these neurons, display normal distribution at the beginning of the cortical neuronogenesis but are absent in the neocortical marginal zone of the mutant mice at the time when the cortical plate is laid down. As a consequence, the development of radial glia is impaired, and neurons making up the cortical plate display abnormal migration patterns. In addition, restricted defects along the rostrocaudal and the mediolateral axes are present in the subplate, suggesting an Emx2-specific role in priming the proper development of this layer.
Articolo in rivista - Articolo scientifico
Animals; Cell Adhesion Molecules, Neuronal; Cell Movement; Cerebral Cortex; Embryo, Mammalian; Embryonic and Fetal Development; Extracellular Matrix Proteins; Female; Homeodomain Proteins; Mice; Mice, Inbred Strains; Mice, Knockout; Mutation; Nerve Tissue Proteins; Neuroglia; Neurons; Serine Endopeptidases; Signal Transduction; Transcription Factors
English
2000
20
3
1109
1118
none
Mallamaci, A., Mercurio, S., Muzio, L., Cecchi, C., Pardini, C., Gruss, P., et al. (2000). The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex. THE JOURNAL OF NEUROSCIENCE, 20(3), 1109-1118.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/105821
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