We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle- to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.
Godi, A., Facchetti, A., Bissett, S., COCUZZA, C., Miller, E., & Beddows, S. (2016). Naturally occurring major and minor capsid protein variants of human papillomavirus 45 (HPV45): Differential recognition by cross-neutralizing antibodies generated by HPV vaccines. JOURNAL OF VIROLOGY, 90(6), 3247-3252.
Citazione: | Godi, A., Facchetti, A., Bissett, S., COCUZZA, C., Miller, E., & Beddows, S. (2016). Naturally occurring major and minor capsid protein variants of human papillomavirus 45 (HPV45): Differential recognition by cross-neutralizing antibodies generated by HPV vaccines. JOURNAL OF VIROLOGY, 90(6), 3247-3252. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | Si |
Titolo: | Naturally occurring major and minor capsid protein variants of human papillomavirus 45 (HPV45): Differential recognition by cross-neutralizing antibodies generated by HPV vaccines |
Autori: | Godi, A; Facchetti, A; Bissett, S; COCUZZA, C; Miller, E; Beddows, S |
Autori: | |
Data di pubblicazione: | 2016 |
Lingua: | English |
Rivista: | JOURNAL OF VIROLOGY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1128/JVI.02859-15 |
Appare nelle tipologie: | 01 - Articolo su rivista |
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