This paper explores the effects of covariates such as age, gender, chronological time of seroconversion, and mode of virus transmission on the interval between HIV seroconversion and the development of AIDS. For many cohorts which are available to provide information about such effects, both the time of seroconversion and the time of onset of AIDS may be right- or interval-censored. To analyse these doubly-censored data, we propose a method in which we first estimate the marginal distribution of the chronological time of seroconversion and use this distribution to impute the seroconversion time for each subject. Subsequently, we estimate the distribution of induction times conditional on the seroconversion distribution. We apply this technique to a cohort of HIV seropositive subjects recruited from various outpatient facilities throughout Italy and show that age at seroconversion has the greatest effect on induction time

Gauvreau, K., Degruttola, V., Pagano, M., & Bellocco, R. (1994). The effect of covariates on the induction time of AIDS using improved imputation of exact seroconversion times. STATISTICS IN MEDICINE, 13(19-20), 2021-2030.

The effect of covariates on the induction time of AIDS using improved imputation of exact seroconversion times

BELLOCCO, RINO
Ultimo
1994

Abstract

This paper explores the effects of covariates such as age, gender, chronological time of seroconversion, and mode of virus transmission on the interval between HIV seroconversion and the development of AIDS. For many cohorts which are available to provide information about such effects, both the time of seroconversion and the time of onset of AIDS may be right- or interval-censored. To analyse these doubly-censored data, we propose a method in which we first estimate the marginal distribution of the chronological time of seroconversion and use this distribution to impute the seroconversion time for each subject. Subsequently, we estimate the distribution of induction times conditional on the seroconversion distribution. We apply this technique to a cohort of HIV seropositive subjects recruited from various outpatient facilities throughout Italy and show that age at seroconversion has the greatest effect on induction time
Articolo in rivista - Articolo scientifico
Acquired Immunodeficiency Syndrome; Adult; Age of Onset; Cohort Studies; Female; HIV Infections; Homosexuality; Humans; Italy; Likelihood Functions; Male; Population Surveillance; Sex Factors; Sexual Behavior; Substance Abuse, Intravenous; Time Factors; HIV Seropositivity; Models, Biological
English
2021
2030
10
Gauvreau, K., Degruttola, V., Pagano, M., & Bellocco, R. (1994). The effect of covariates on the induction time of AIDS using improved imputation of exact seroconversion times. STATISTICS IN MEDICINE, 13(19-20), 2021-2030.
Gauvreau, K; Degruttola, V; Pagano, M; Bellocco, R
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/103612
Citazioni
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 20
Social impact