Evidence on the association of nondipping pattern with carotid atherosclerosis is scarce. We performed a meta-analysis in order to provide comprehensive information on subclinical carotid alterations in nondipping as compared with dipping individuals. A computerized search was performed using PubMed, OVID, EMBASE and Cochrane library databases from 1 January 1990 up to 31 March 2015. Full articles providing data on carotid intima-media thickness (IMT) and plaque in nondipping and dipping individuals, as assessed by ultrasonography, were analyzed. A total of 2753 adult individuals (1003 nondipping and 1750 dipping) included in 13 studies were considered. Common carotid IMT was higher in nondipping than in dipping individuals [807±36μm vs. 746±28μm, standard means difference, SMD: 0.37±0.09, confidence interval (CI): 0.19-0.56, P<0.01]. From data on plaque prevalence provided by five studies, the odds ratio for carotid plaques resulted 67% higher in nondipping (95% CI: 1.26-2.21, P<0.01) than in dipping individuals. Our findings support an association between nondipping pattern and increased risk of subclinical carotid alterations. In a practical perspective, the present meta-analysis reinforces the view that an effective blood pressure control over the entire 24-h period, in particular at night, may prevent the progression of vascular damage associated with nondipping phenotype.
Cuspidi, C., Sala, C., Tadic, M., Gherbesi, E., Grassi, G., & Mancia, G. (2016). Nondipping pattern and carotid atherosclerosis: A systematic review and meta-analysis. JOURNAL OF HYPERTENSION, 34(3), 385-392.
|Citazione:||Cuspidi, C., Sala, C., Tadic, M., Gherbesi, E., Grassi, G., & Mancia, G. (2016). Nondipping pattern and carotid atherosclerosis: A systematic review and meta-analysis. JOURNAL OF HYPERTENSION, 34(3), 385-392.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Nondipping pattern and carotid atherosclerosis: A systematic review and meta-analysis|
|Autori:||Cuspidi, C; Sala, C; Tadic, M; Gherbesi, E; Grassi, G; Mancia, G|
CUSPIDI, CESARE (Primo) (Corresponding)
GRASSI, GUIDO (Penultimo)
MANCIA, GIUSEPPE (Ultimo)
|Data di pubblicazione:||2016|
|Rivista:||JOURNAL OF HYPERTENSION|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/HJH.0000000000000812|
|Appare nelle tipologie:||01 - Articolo su rivista|