Full-right-full-left split liver transplantation divides a donor liver into two grafts to be transplanted in adult-size patients. Major technical and organizational difficulties have limited its application to few single center series. We retrospectively analyzed the long-term results of the first multicenter series of this procedure with graft sharing. Between November 1998 and January 2005, 43 transplants were performed by five centers from 23 full-right-full-left in situ split liver procedures; 65% of the grafts were shared. A total of 31 (72%) patients had complications above grade II; 3 (6.9%) were retransplanted. Hospital mortality was 23% with sepsis as the main cause. Six patients died in the long term, two of them for a road accident. A total of 27 patients are alive after a median follow-up of 3200 days (2035-4256). Actuarial survival at 1 and 10 years were 72.1%, 62.6% and 65.1%, 57.9%, respectively for patients and grafts. These figures are similar to those reported for adult living donor liver transplantation by the European Registry over a similar period. Multicenter collaboration in sharing of these grafts is feasible and can help facing the organizational limits, thus increasing diffusion of full-right-full-left split liver transplantation. Full right and full left grafts from split liver procedures can be shared among different centers of the same area in the context of a collaborative activity, being safely and effectively transplanted in adult patients, thus optimizing the use of deceased donor livers. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons

Zambelli, M., Andorno, E., DE CARLIS, L., Rossi, G., Cillo, U., De Feo, T., et al. (2012). Full-right-full-left split liver transplantation: The retrospective analysis of an early multicenter experience including graft sharing. AMERICAN JOURNAL OF TRANSPLANTATION, 12(8), 2198-2210 [10.1111/j.1600-6143.2012.04071.x].

Full-right-full-left split liver transplantation: The retrospective analysis of an early multicenter experience including graft sharing

DE CARLIS, LUCIANO GREGORIO;Colledan, M.
2012

Abstract

Full-right-full-left split liver transplantation divides a donor liver into two grafts to be transplanted in adult-size patients. Major technical and organizational difficulties have limited its application to few single center series. We retrospectively analyzed the long-term results of the first multicenter series of this procedure with graft sharing. Between November 1998 and January 2005, 43 transplants were performed by five centers from 23 full-right-full-left in situ split liver procedures; 65% of the grafts were shared. A total of 31 (72%) patients had complications above grade II; 3 (6.9%) were retransplanted. Hospital mortality was 23% with sepsis as the main cause. Six patients died in the long term, two of them for a road accident. A total of 27 patients are alive after a median follow-up of 3200 days (2035-4256). Actuarial survival at 1 and 10 years were 72.1%, 62.6% and 65.1%, 57.9%, respectively for patients and grafts. These figures are similar to those reported for adult living donor liver transplantation by the European Registry over a similar period. Multicenter collaboration in sharing of these grafts is feasible and can help facing the organizational limits, thus increasing diffusion of full-right-full-left split liver transplantation. Full right and full left grafts from split liver procedures can be shared among different centers of the same area in the context of a collaborative activity, being safely and effectively transplanted in adult patients, thus optimizing the use of deceased donor livers. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons
Articolo in rivista - Articolo scientifico
adult to adult; Adults; full-right-full-left graft; graft sharing; partial graft; Split liver; splitting technique; Adolescent; Adult; Female; Humans; Male; Middle Aged; Organ Size; Retrospective Studies; Survival Analysis; Young Adult; Liver Transplantation; Transplantation; Immunology and Allergy; Pharmacology (medical)
English
2012
12
8
2198
2210
none
Zambelli, M., Andorno, E., DE CARLIS, L., Rossi, G., Cillo, U., De Feo, T., et al. (2012). Full-right-full-left split liver transplantation: The retrospective analysis of an early multicenter experience including graft sharing. AMERICAN JOURNAL OF TRANSPLANTATION, 12(8), 2198-2210 [10.1111/j.1600-6143.2012.04071.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/101037
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