In six male anesthetized, tracheotomized, and mechanically ventilated rabbits we derived indications on alveolar mechanics from in vivo imaging, using a "pleural window" technique (pleural space intact) that allows unrestrained movement of the same subpleural alveoli (N=60) on increasing alveolar pressure from 4 to 8cmH2O. Absolute compliance (Cabs, ratio of change in alveolar surface area to the change in alveolar pressure) was significantly lower in smaller compared to larger alveoli. Specific compliance, Csp, obtained by normalizing Cabs to alveolar surface area, was essentially independent of alveolar size. Both Cabs and Csp were affected by large variability likely reflecting the complex matching between elastic and surface forces. We hypothesize that the relative constancy of Csp might contribute to reduce interregional differences in parenchymal and surface forces in the lung tissue by contributing to assure a uniform stretching in a model of mechanically inter-dependent alveoli. © 2014 Elsevier B.V.

Salito, C., Aliverti, A., Rivolta, I., Mazzuca, E., Miserocchi, G. (2014). Alveolar mechanics studied by in vivo microscopy imaging through intact pleural space. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 202, 44-49 [10.1016/j.resp.2014.07.012].

Alveolar mechanics studied by in vivo microscopy imaging through intact pleural space

RIVOLTA, ILARIA;MISEROCCHI, GIUSEPPE ANDREA
Ultimo
2014

Abstract

In six male anesthetized, tracheotomized, and mechanically ventilated rabbits we derived indications on alveolar mechanics from in vivo imaging, using a "pleural window" technique (pleural space intact) that allows unrestrained movement of the same subpleural alveoli (N=60) on increasing alveolar pressure from 4 to 8cmH2O. Absolute compliance (Cabs, ratio of change in alveolar surface area to the change in alveolar pressure) was significantly lower in smaller compared to larger alveoli. Specific compliance, Csp, obtained by normalizing Cabs to alveolar surface area, was essentially independent of alveolar size. Both Cabs and Csp were affected by large variability likely reflecting the complex matching between elastic and surface forces. We hypothesize that the relative constancy of Csp might contribute to reduce interregional differences in parenchymal and surface forces in the lung tissue by contributing to assure a uniform stretching in a model of mechanically inter-dependent alveoli. © 2014 Elsevier B.V.
Articolo in rivista - Articolo scientifico
Alveolar mechanics; Compliance; In vivo microscopy imaging; Analysis of Variance; Animals; Bronchoscopy; Extracellular Space; Image Processing, Computer-Assisted; Lung Compliance; Male; Pulmonary Alveoli; Rabbits; Respiratory Mechanics; Physiology; Pulmonary and Respiratory Medicine; Neuroscience (all); Medicine (all)
English
44
49
6
Salito, C., Aliverti, A., Rivolta, I., Mazzuca, E., Miserocchi, G. (2014). Alveolar mechanics studied by in vivo microscopy imaging through intact pleural space. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 202, 44-49 [10.1016/j.resp.2014.07.012].
Salito, C; Aliverti, A; Rivolta, I; Mazzuca, E; Miserocchi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/100358
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