Background: The clinical benefits of prophylaxis in patients with hemophilia are well-established and include the following: reduced bleeding episodes, prevention of joint damage, decreased inhibitor development, and improved health-related quality of life. However, the cost-effectiveness of prophylaxis is still not clear. Procedures: We reviewed the published hemophilia prophylaxis economic models focusing on utility assumptions. Results: We found six cost-utility studies that compared prophylaxis and on-demand regimens. These studies reported remarkably different results, using utility values based on different assumptions and data sources. Conclusions: We suggest that cooperation among key stakeholders (clinicians, patient organizations and health-care decision makers) as a means of collecting evidence-based and experiential data to represent both the utility and the quality of life changes for patients with Hemophilia A who are treated with prophylaxis or receive on-demand treatments may represent a winning strategy with which to resolve the outstanding issues related to health technology assessments in the care of patients with hemophilia. Pediatr Blood Cancer 2015;62:1826-1831.
Valente, M., Cortesi, P., Lassandro, G., Mathew, P., Pocoski, J., Molinari, A., et al. (2015). Health economic models in hemophilia A and utility assumptions from a clinician's perspective. PEDIATRIC BLOOD & CANCER, 62(10), 1826-1831 [10.1002/pbc.25543].
|Citazione:||Valente, M., Cortesi, P., Lassandro, G., Mathew, P., Pocoski, J., Molinari, A., et al. (2015). Health economic models in hemophilia A and utility assumptions from a clinician's perspective. PEDIATRIC BLOOD & CANCER, 62(10), 1826-1831 [10.1002/pbc.25543].|
|Tipo:||Articolo in rivista - Review Essay|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Health economic models in hemophilia A and utility assumptions from a clinician's perspective|
|Autori:||Valente, M; Cortesi, P; Lassandro, G; Mathew, P; Pocoski, J; Molinari, A; Mantovani, L; Giordano, P|
CORTESI, PAOLO ANGELO (Secondo)
MANTOVANI, LORENZO GIOVANNI (Penultimo)
|Data di pubblicazione:||2015|
|Rivista:||PEDIATRIC BLOOD & CANCER|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/pbc.25543|
|Appare nelle tipologie:||01 - Articolo su rivista|