The inhibition of the oncogenic variants of Ras proteins represents an interesting and promising research field for the development of new anticancer therapies. During this thesis several important data were collected in order to clarify the structure activity relationship in Ras-inhibitors. Then new lead compounds derived from natural carbohydrates were designed and synthesized following a rational drug design approach. These original water-soluble molecules were investigated for the biological activity point of view; in addition the binding to human Ras was fully investigated, identifying the ligand-Ras binding interface.
(2009). Synthesis and biological characterization of new molecules pharnacologically active derived from natural compouds. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2009).
Synthesis and biological characterization of new molecules pharnacologically active derived from natural compouds
PALMIOLI, ALESSANDRO
2009-12-11
Abstract
The inhibition of the oncogenic variants of Ras proteins represents an interesting and promising research field for the development of new anticancer therapies. During this thesis several important data were collected in order to clarify the structure activity relationship in Ras-inhibitors. Then new lead compounds derived from natural carbohydrates were designed and synthesized following a rational drug design approach. These original water-soluble molecules were investigated for the biological activity point of view; in addition the binding to human Ras was fully investigated, identifying the ligand-Ras binding interface.
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