The present invention concerns a family of sugar-based molecules for therapeutic use, comprising compounds with a structure having at least one sugar molecule with carrier function, bound to arsenic having active principle function, allowing the selective therapeutic treatment of tumoral pathologies and not, distinguished by a high cellular metabolism and, consequently, by a high glucose consumption. On the base of the preferential glucose absorption according to the Warburg effect, said compounds are adapted to penetrate inside tumoral cells and not, distinguished by a high cellular metabolism, by means of the glucose molecule integrated in their structure, so as to determine the selective therapeutic treatment of said cells and, consequently, of the pathologies deriving therefrom, by means of the arsenic molecule chemically bound to above mentioned glucose molecule.; Also a process for the production of synthetic sugar-based compounds is the object of the present invention, as well as a process for the production of extracted sugar-based compounds, produced from natural sources
Nicotra, F., LA FERLA, B., Pitaro, M., Salvetti, M., Codacci Pisanelli, G., Ristori, G. (2012)A Family of Sugar-Based Molecules for Therapeutic Use and Process for the Production Thereof. . Brevetto No. IT2012RM00058 20120220.
A Family of Sugar-Based Molecules for Therapeutic Use and Process for the Production Thereof
NICOTRA, FRANCESCO;LA FERLA, BARBARA;
2012
Abstract
The present invention concerns a family of sugar-based molecules for therapeutic use, comprising compounds with a structure having at least one sugar molecule with carrier function, bound to arsenic having active principle function, allowing the selective therapeutic treatment of tumoral pathologies and not, distinguished by a high cellular metabolism and, consequently, by a high glucose consumption. On the base of the preferential glucose absorption according to the Warburg effect, said compounds are adapted to penetrate inside tumoral cells and not, distinguished by a high cellular metabolism, by means of the glucose molecule integrated in their structure, so as to determine the selective therapeutic treatment of said cells and, consequently, of the pathologies deriving therefrom, by means of the arsenic molecule chemically bound to above mentioned glucose molecule.; Also a process for the production of synthetic sugar-based compounds is the object of the present invention, as well as a process for the production of extracted sugar-based compounds, produced from natural sources
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