The present invention relates to a novel process for the preparation of 2,4,6-triiodoisophthalic bisamide derivatives, which are useful intermediates in the preparation of non-ionic X-ray contrast agents, starting from the corresponding acyl chloride intermediates which are amidated in a mixture of specific hydrotropic solvents in the presence of a low amount of water. In addition, the invention relates to the use of such hydrotropic solvents in the preparation of said 2,4,6-triiodoisophthalic bisamide intermediates to produce non-ionic X-ray contrast agents.
Lattuada, L., Beverina, L., Sassi, M., Mattiello, S., Papagni, A., Zucchi, A. (2022)Process for the preparation of 2,4,6-triiodoisophthalic bisamides. . Brevetto No. PCT/EP2022/086082.
Process for the preparation of 2,4,6-triiodoisophthalic bisamides
Beverina, Luca;Sassi Mauro;Mattiello, Sara;Papagni, Antonio;Zucchi, Anita.
2022
Abstract
The present invention relates to a novel process for the preparation of 2,4,6-triiodoisophthalic bisamide derivatives, which are useful intermediates in the preparation of non-ionic X-ray contrast agents, starting from the corresponding acyl chloride intermediates which are amidated in a mixture of specific hydrotropic solvents in the presence of a low amount of water. In addition, the invention relates to the use of such hydrotropic solvents in the preparation of said 2,4,6-triiodoisophthalic bisamide intermediates to produce non-ionic X-ray contrast agents.
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