The role of NK cells in anti-viral and anti-tumor immunity has been extensively studied, nevertheless the mechanisms involved in the activation of NK cells in an anti-bacterial remain to be fully understood. Recent studies have shown that activation of NK cells by various pathogens is indirect and is driven by accessory cells, particularly by DCs. (Cerwenka and Lanier 2001, Newman and Riley 2007). We have studied how DC can activate NK cells in the presence of LPS, the main component of the Gram-negative cell wall, which is recognized by TLR-4 (Akira 2006). We decided to focus our attention primerely on the production of IFN-γ by NK cells because their anti-bacterial effects are mainly mediated by this cytokine (Boehm, Klamp et al. 1997). Here we show the molecular mechanisms underlying the activation of NK cells mediated by DC (in vitro and in vivo) upon LPS exposure.

(2011). Mechanism of dc-mediated nk cell activation. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011).

Mechanism of dc-mediated nk cell activation

BODIO, CATERINA
2011

Abstract

The role of NK cells in anti-viral and anti-tumor immunity has been extensively studied, nevertheless the mechanisms involved in the activation of NK cells in an anti-bacterial remain to be fully understood. Recent studies have shown that activation of NK cells by various pathogens is indirect and is driven by accessory cells, particularly by DCs. (Cerwenka and Lanier 2001, Newman and Riley 2007). We have studied how DC can activate NK cells in the presence of LPS, the main component of the Gram-negative cell wall, which is recognized by TLR-4 (Akira 2006). We decided to focus our attention primerely on the production of IFN-γ by NK cells because their anti-bacterial effects are mainly mediated by this cytokine (Boehm, Klamp et al. 1997). Here we show the molecular mechanisms underlying the activation of NK cells mediated by DC (in vitro and in vivo) upon LPS exposure.
GRANUCCI, FRANCESCA
Dendritic cells,Natural Killer cells, Cytokines, inflammasome, LPS
MED/04 - PATOLOGIA GENERALE
English
29-mar-2011
Scuola di Dottorato in Medicina Traslazionale e Molecolare
MEDICINA TRASLAZIONALE E MOLECOLARE (DIMET) - 45R
23
2009/2010
open
(2011). Mechanism of dc-mediated nk cell activation. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/20196
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