IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishVarious types of nanoparticles (NPs), such as Liposomes, Solid Lipid NPs and Polymeric NPs, are being extensively explored for their potentialities in the medical field. NPs are attractive tools in biomedical applications thanks to their biocompatibility, non-immunogenicity, non-toxicity, biodegradability, high physical stability, possibility of drug loading and releasing, and higher probability for surface functionalization. The project is devoted to the synthesis of NPs functionalized with amyloid-beta ligands (Aβ-ligands), imaging tools and/or blood brain barrier-transporters (BBB-transporters) for the cure and the diagnosis of Alzheimer’s disease (AD). Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD). It has been previously shown that some small molecules targets Aβ plaques and, among them, curcumin interacts with their precursors, suggesting a potential role for the prevention or the treatment of AD. Herein, a chemoselective ligation procedure was used to generate NPs decorated with a curcumin derivative, designed to maintain all the features required for interaction with Aβ. In summary, this thesis describes the preparation and characterization of new curcumin derivatives and NPs, with affinity for Aβ peptide. They could be exploited as ligands and/or vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD. The NPs preparations and the biological results were obtained in collaboration with scientists involved in a joint European project: NAD - Nanoparticles for therapy and diagnosis of Alzheimer’s Disease - 2008-2012, FP7-NMP-2007-LARGE-1-Large-scale integrating project NMP-2007-4.0-4 Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy.
(2011). Design and systhesis of nanoparticles for therapy and imaging of Alzheimer's disease. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011).
| Autori: | |
| Tutore: | NICOTRA, FRANCESCO |
| Data di pubblicazione: | 10-feb-2011 |
| Titolo: | Design and systhesis of nanoparticles for therapy and imaging of Alzheimer's disease |
| Settore Scientifico Disciplinare: | CHIM/06 - CHIMICA ORGANICA |
| Lingua: | English |
| Scuola di dottorato: | Scuola di dottorato di Scienze |
| Corso di dottorato: | SCIENZE CHIMICHE - 18R |
| Ciclo: | 23 |
| Anno Accademico: | 2009/2010 |
| Citazione: | (2011). Design and systhesis of nanoparticles for therapy and imaging of Alzheimer's disease. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011). |
| Parole Chiave: | Nanoparticles (NPs), Amyloid-beta peptide (A-beta), Alzheimer’s disease (AD), Small Molecules, Curcumin, Click Chemistry, Stability, Affinity |
| Appare nelle tipologie: | 07 - Tesi di dottorato Bicocca post 2009 |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| phd_unimib_716391.pdf | Doctoral thesis | Open Access Visualizza/Apri |
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