Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; n=145) or walking exercise (n=151); 227 patients (exercise n=104; control n=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance +/- SD: baseline, 328 +/- 96 m; 6 months, 367 +/- 113 m) but not in the control group (baseline, 321 +/- 107 m; 6 months, 324 +/- 116 m; P<0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time SD: baseline, 20.5 +/- 6.0 seconds; 6 months, 18.2 +/- 5.7 seconds) but not in the control group (baseline, 20.9 +/- 5.8 seconds; 6 months, 20.2 +/- 6.4 seconds; P=0.001 between groups). The cognitive function score (P=0.04) and quality of social interaction score (P=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis.

Manfredini, F., Mallamaci, F., D'Arrigo, G., Baggetta, R., Bolignano, D., Torino, C., et al. (2017). Exercise in patients on dialysis: A multicenter, randomized clinical trial. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(4), 1259-1268 [10.1681/ASN.2016030378].

Exercise in patients on dialysis: A multicenter, randomized clinical trial

Provenzano, Pf;
2017

Abstract

Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; n=145) or walking exercise (n=151); 227 patients (exercise n=104; control n=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance +/- SD: baseline, 328 +/- 96 m; 6 months, 367 +/- 113 m) but not in the control group (baseline, 321 +/- 107 m; 6 months, 324 +/- 116 m; P<0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time SD: baseline, 20.5 +/- 6.0 seconds; 6 months, 18.2 +/- 5.7 seconds) but not in the control group (baseline, 20.9 +/- 5.8 seconds; 6 months, 20.2 +/- 6.4 seconds; P=0.001 between groups). The cognitive function score (P=0.04) and quality of social interaction score (P=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis.
CKD; dialysis; exercise; physical functioning; rehabilitation; six minute walking test; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Exercise Therapy; Physical Fitness; Quality of Life; Renal Dialysis; Walking; Nephrology
English
2017
Exercise in Patients on Dialysis: A Multicenter, Randomized Clinical Trial
English
Manfredini, F; Mallamaci, F; D'Arrigo, G; Baggetta, R; Bolignano, D; Torino, C; Lamberti, N; Bertoli, S; Ciurlino, D; Rocca-Rey, L; Barillà, A; Battaglia, Y; Rapanà, RM; Zuccalà, A; Bonanno, G; Fatuzzo, P; Rapisarda, F; Rastelli, S; Fabrizi, F; Messa, P; De Paola, L; Lombardi, L; Cupisti, A; Fuiano, G; Lucisano, G; Summaria, C; Felisatti, M; Pozzato, E; Malagoni, AM; Castellino, P; Aucella, F; Abd ElHafeez, S; Provenzano, PF; Tripepi, G; Catizone, L; Zoccali, C
28
4
1259
1268
http://jasn.asnjournals.org/content/28/4/1259.full.pdf+html
Manfredini, F., Mallamaci, F., D'Arrigo, G., Baggetta, R., Bolignano, D., Torino, C., et al. (2017). Exercise in patients on dialysis: A multicenter, randomized clinical trial. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(4), 1259-1268 [10.1681/ASN.2016030378].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/175137
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