IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishTNF-blocking therapy is successfully used in the treatment of immune-mediated and inflammatory diseases. Although the inhibition of inflammatory pathways in target tissues by anti-TNF therapy has been clearly described, the impact of TNF-blockade on peripheral T cell responses in humans is still unclear. Here we studied T cell effector functions in psoriasis patients before and after treatment with anti-TNF by measuring a wide panel of cytokines as well as cell division upon in vitro stimulation. In parallel, the modulation of T cell cytokine gene expression was evaluated in psoriatic skin lesions. Results clearly evidenced that TNF-blockade increases T cell cytokine responses, mainly Th1 and Th17, in peripheral lymphocytes upon stimulation. Importantly, TNF-blockade also induced a potent enhancement of IL-10 expression by different subsets of circulating leukocytes that was found to correlate with the clinical outcome of the therapy. Despite the enhanced T cell cytokine responses in the peripheral circulation, in psoriatic skin lesions the overall effect of TNF-blockade was a diminished expression of Th1 and Th17 cytokine genes, paralleled by augmented expression of Il10. These evidences indicate a negative regulatory role of TNF on T cell activation and effector functions and enlighten a new role for TNF-blockade in the up-regulation of IL-10 that may participate to the shut down of the inflammatory reaction. Ongoing work (1): TNF-blockade enhances T cell response to TcR stimulation. Ongoing work (2): Modulation of cytokine gene expression by TNF-therapy in intestinal mucosa of patients with Inflammatory Bowel Disease
(2009). Effect of anti-TNF therapy on T cell activation and effector functions in patients with chronic inflammatory diseases. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2009).
| Autori: | |
| Data di pubblicazione: | 26-nov-2009 |
| Tutor esterno: | REALI, EVA |
| Titolo: | Effect of anti-TNF therapy on T cell activation and effector functions in patients with chronic inflammatory diseases |
| Settore Scientifico Disciplinare: | MED/04 - PATOLOGIA GENERALE |
| Lingua: | English |
| Scuola di dottorato: | Scuola di Dottorato in Medicina Traslazionale e Molecolare |
| Corso di dottorato: | MEDICINA TRASLAZIONALE E MOLECOLARE (DIMET) - 45R |
| Ciclo: | 22 |
| Anno Accademico: | 2008/2009 |
| Citazione: | (2009). Effect of anti-TNF therapy on T cell activation and effector functions in patients with chronic inflammatory diseases. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2009). |
| Parole Chiave: | anti-TNF; T-cell; cytokines; immune system; inflammatory diseases |
| Appare nelle tipologie: | 07 - Tesi di dottorato Bicocca post 2009 |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| phd_unimib_708362.pdf | Doctoral thesis | Open Access Visualizza/Apri |
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