Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNgamma, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity

Granucci, F., Zanoni, I., Pavelka, N., Van Dommelen, S., Andoniou, C., Belardelli, F., et al. (2004). A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. JOURNAL OF EXPERIMENTAL MEDICINE, 200(3), 287-295 [10.1084/jem.20040370].

A contribution of mouse dendritic cell-derived IL-2 for NK cell activation

GRANUCCI, FRANCESCA;ZANONI, IVAN;CASTAGNOLI, PAOLA
2004

Abstract

Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNgamma, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity
Articolo in rivista - Articolo scientifico
Lymphocyte Activation; Animals; Killer Cells, Natural; Cytotoxicity, Immunologic; Interferon-gamma; Dendritic Cells; Cell Communication; Interleukin-2; Interleukin-18; Mice; Interleukin-12; Mice, Inbred C57BL; Mice, Inbred BALB C
English
2004
200
3
287
295
reserved
Granucci, F., Zanoni, I., Pavelka, N., Van Dommelen, S., Andoniou, C., Belardelli, F., et al. (2004). A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. JOURNAL OF EXPERIMENTAL MEDICINE, 200(3), 287-295 [10.1084/jem.20040370].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14475
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