The authors studied the influence of Silybin in rats, administered i.p. for 7 days (daily dose of 100 mg/kg/b.w.) on the biliary lipid composition and on the maximal excretory rate of bile salts. Following this treatment, biliary cholesterol excretion was reduced, while the other lipids and bile flow were not significantly modified. After sodium cholate infusion (1.6 mumol/min/100 g b.w. i.v. for 80 minutes), the Tm of bile salts and bile flow remained unchanged in Silybin pretreated rats. The mechanism by which Silybin treatment reduces cholesterol excretion, is discussed

Nassuato, G., Iemmolo, R., Lirussi, F., Orlando, R., Giacon, L., Venuti, M., et al. (1983). Effect of Silybin on biliary lipid composition in rats. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 15(4), 337-346 [10.1016/S0031-6989(83)80043-5].

Effect of Silybin on biliary lipid composition in rats

Strazzabosco, M;
1983

Abstract

The authors studied the influence of Silybin in rats, administered i.p. for 7 days (daily dose of 100 mg/kg/b.w.) on the biliary lipid composition and on the maximal excretory rate of bile salts. Following this treatment, biliary cholesterol excretion was reduced, while the other lipids and bile flow were not significantly modified. After sodium cholate infusion (1.6 mumol/min/100 g b.w. i.v. for 80 minutes), the Tm of bile salts and bile flow remained unchanged in Silybin pretreated rats. The mechanism by which Silybin treatment reduces cholesterol excretion, is discussed
Articolo in rivista - Articolo scientifico
sylibin, biliary lipids, rat, liver
English
1983
15
4
337
346
none
Nassuato, G., Iemmolo, R., Lirussi, F., Orlando, R., Giacon, L., Venuti, M., et al. (1983). Effect of Silybin on biliary lipid composition in rats. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 15(4), 337-346 [10.1016/S0031-6989(83)80043-5].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/8470
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 9
Social impact