In order to investigate whether addition of beta 1-selective agonism can interfere with the antihypertensive efficacy of beta 1-selective adrenoceptor blockers, two separate studies were carried out to evaluate the effects on blood pressure and heart rate of three beta 1-selective blockers with or without varying degree of beta 1-selective agonism. In hypertensive patients at rest, the greatest blood pressure reduction and bradycardia were found with atenolol, a beta 1-selective blocker without any agonistic activity; a consistently smaller effect on blood pressure and heart rate was observed with Visacor (ICI 141 292), a beta 1-selective blocker with moderate beta 1-selective agonism, whereas no clinically relevant decrease in blood pressure occurred with Corwin (ICI 118 587), the beta 1-selective blocker with high beta 1-selective agonism. In contrast, during exercise-induced sympathetic activation, all three compounds reduced systolic blood pressure and heart rate to a similar degree

Leonetti, G., Sampieri, L., Cuspidi, C., Terzoli, L., Rupoli, L., Fruscio, M., et al. (1985). Does beta 1-selective agonistic activity interfere with the antihypertensive efficacy of beta 1-selective blocking agents?. JOURNAL OF HYPERTENSION SUPPLEMENT, 3(Suppl 3), S243-S245.

Does beta 1-selective agonistic activity interfere with the antihypertensive efficacy of beta 1-selective blocking agents?

CUSPIDI, CESARE;
1985

Abstract

In order to investigate whether addition of beta 1-selective agonism can interfere with the antihypertensive efficacy of beta 1-selective adrenoceptor blockers, two separate studies were carried out to evaluate the effects on blood pressure and heart rate of three beta 1-selective blockers with or without varying degree of beta 1-selective agonism. In hypertensive patients at rest, the greatest blood pressure reduction and bradycardia were found with atenolol, a beta 1-selective blocker without any agonistic activity; a consistently smaller effect on blood pressure and heart rate was observed with Visacor (ICI 141 292), a beta 1-selective blocker with moderate beta 1-selective agonism, whereas no clinically relevant decrease in blood pressure occurred with Corwin (ICI 118 587), the beta 1-selective blocker with high beta 1-selective agonism. In contrast, during exercise-induced sympathetic activation, all three compounds reduced systolic blood pressure and heart rate to a similar degree
Articolo in rivista - Articolo scientifico
Beta 1-selective agonistic activity
English
1985
3
Suppl 3
S243
S245
none
Leonetti, G., Sampieri, L., Cuspidi, C., Terzoli, L., Rupoli, L., Fruscio, M., et al. (1985). Does beta 1-selective agonistic activity interfere with the antihypertensive efficacy of beta 1-selective blocking agents?. JOURNAL OF HYPERTENSION SUPPLEMENT, 3(Suppl 3), S243-S245.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/83558
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