This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is elicited by the association in the same molecule a carbohydrate, as B-cell antigen, and a peptide, or an entire protein, as T-cell epitope. We will review on the synthesis and the immunological investigation of various glycoconjugates presenting tumor-associated carbohydrate antigens. Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential anti-tumour therapeutics will be considered.

Cipolla, L., Peri, F., Airoldi, C. (2008). Glycoconjugates in cancer therapy. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 8(1), 92-121 [10.2174/187152008783330815].

Glycoconjugates in cancer therapy

CIPOLLA, LAURA FRANCESCA;PERI, FRANCESCO;AIROLDI, CRISTINA
2008

Abstract

This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is elicited by the association in the same molecule a carbohydrate, as B-cell antigen, and a peptide, or an entire protein, as T-cell epitope. We will review on the synthesis and the immunological investigation of various glycoconjugates presenting tumor-associated carbohydrate antigens. Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential anti-tumour therapeutics will be considered.
Articolo in rivista - Articolo scientifico
Glycopeptides, glyconanoparticles, tumour-associated carbohydrate antigens, glycoconjugates, anti-tumour vaccines
English
2008
8
1
92
121
none
Cipolla, L., Peri, F., Airoldi, C. (2008). Glycoconjugates in cancer therapy. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 8(1), 92-121 [10.2174/187152008783330815].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/8239
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