In the last decades we have come to understand that the hypothalamus is a key region in controlling energy homeostasis. A number of control models have been proposed to explain the regulation of feeding behavior in physiological and pathological conditions, but all those based on imbalances of single factors fail to explain the disrupted regulation of energy supply in eating disorders such as anorexia nervosa and bulimia nervosa, as well as other psychiatric disorders. A growing amount of evidence demonstrates that many signaling molecules originated within the brain or coming from the adipose tissue or the gastro-enteric tract are involved in the highly complex process controlling food intake and energy expenditure. The recent discovery of leptin, ghrelin, and other factors have made it possible to penetrate in the still undefined pathophysiology of eating disorders with the hope of finding effective treatments for such diseases.

Torsello, A., Brambilla, F., Tamiazzo, L., Bulgarelli, I., Rapetti, D., Bresciani, E., et al. (2007). Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 30(11), 962-976 [10.1007/BF03349245].

Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa

TORSELLO, ANTONIO BIAGIO;BRESCIANI, ELENA;LOCATELLI, VITTORIO
2007

Abstract

In the last decades we have come to understand that the hypothalamus is a key region in controlling energy homeostasis. A number of control models have been proposed to explain the regulation of feeding behavior in physiological and pathological conditions, but all those based on imbalances of single factors fail to explain the disrupted regulation of energy supply in eating disorders such as anorexia nervosa and bulimia nervosa, as well as other psychiatric disorders. A growing amount of evidence demonstrates that many signaling molecules originated within the brain or coming from the adipose tissue or the gastro-enteric tract are involved in the highly complex process controlling food intake and energy expenditure. The recent discovery of leptin, ghrelin, and other factors have made it possible to penetrate in the still undefined pathophysiology of eating disorders with the hope of finding effective treatments for such diseases.
Articolo in rivista - Articolo scientifico
anorexia; bulimia; appetite control; endocrine disregulation; feeding behavior
English
dic-2007
30
11
962
976
none
Torsello, A., Brambilla, F., Tamiazzo, L., Bulgarelli, I., Rapetti, D., Bresciani, E., et al. (2007). Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 30(11), 962-976 [10.1007/BF03349245].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/810
Citazioni
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 11
Social impact