By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a 15N-edited HSQC NMR experiment the ligand-Ras binding interface
Palmioli, A., Sacco, E., Abraham, S., Thomas, C., DI DOMIZIO, A., DE GIOIA, L., et al. (2009). First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(15), 4217-4222 [10.1016/j.bmcl.2009.05.107].
First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand
PALMIOLI, ALESSANDRO;SACCO, ELENA;DI DOMIZIO, ALESSANDRO;DE GIOIA, LUCA;VANONI, MARCO ERCOLE;PERI, FRANCESCO
2009
Abstract
By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a 15N-edited HSQC NMR experiment the ligand-Ras binding interface
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