The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells. © 2014 American Chemical Society.
Avvakumova, S., Galbiati, E., Pandolfi, L., Mazzucchelli, S., Cassani, M., Gori, A., et al. (2014). Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells. BIOCONJUGATE CHEMISTRY, 25(8), 1381-1386 [10.1021/bc500202b].
Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells
AVVAKUMOVA, SVETLANA;GALBIATI, ELISABETTA;PANDOLFI, LAURA;MAZZUCCHELLI, SERENA;PROSPERI, DAVIDE
2014
Abstract
The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells. © 2014 American Chemical Society.
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