The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament destined to diminish the resistance to chemotherapeutic drugs in the therapeutic treatment of epithelial tumor pathologies. Also described is a method for the determination of the drug resistance in tumor cells, as well as a method for the identification of tumor stem cells

Lavitrano, M., Grassilli, E., Helin, K. (2008)Isoform of bruton's tyrosine kinase (BTK) protein. . Brevetto No. PCT/EP2008/053099.

Isoform of bruton's tyrosine kinase (BTK) protein

LAVITRANO, MARIALUISA;GRASSILLI, EMANUELA;
2008

Abstract

The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament destined to diminish the resistance to chemotherapeutic drugs in the therapeutic treatment of epithelial tumor pathologies. Also described is a method for the determination of the drug resistance in tumor cells, as well as a method for the identification of tumor stem cells
siRNA, drug resistance, epithelial tumors
Human necessities
English
Rilevanza internazionale
14-mar-2008
PCT/EP2008/053099
1-apr-2010
US 20100081704 A1
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Lavitrano, M., Grassilli, E., Helin, K. (2008)Isoform of bruton's tyrosine kinase (BTK) protein. . Brevetto No. PCT/EP2008/053099.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/61781
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